Table 4.

Synthesis of benzonaphthyridinones and a dibenzonaphthyridinone^a

Entry	Aryne precursor	Amine	Product	Yieldb (%)
1				56
2				48
3				53
4				52
5				48
6				66
7				72
8				50
9				32

^aAll reactions were carried out on a 0.25 mmol scale with 2 equiv of CsF at room temperature. A solution of 1 in 4 mL of MeCN (solution A) and a solution of 4 and sF in 4 mL of MeCN (solution B) were prepared separately. Solution A was slowly added to solution B with a syringe pump over 8 h, the resulting solution was stirred for an additional 16 h.

^bIsolated yield.