Figure 4.

Simulations based on the ^99mTc–mebrofenin semiphysiologically based pharmacokinetic model scheme (Figure 2) for ^99mTc–mebrofenin (a) blood, and (b) liver concentration–time data, and (c) cumulative % dose excreted in bile resulting from parameters describing mean control data (Table 2) and the following changes in transport-mediated processes, alone and in combination. Mean control data (red); 1/3 CL_uptake,h + 3x CL_efflux,h (blue); 1/2 CL_uptake,h and CL_uptake,o + 2x CL_efflux,h and CL_efflux,o (dashed black); 1/2 CL_biliary (solid black); mean control data without extrahepatic compartment (gray).