Table 1.
Presence of Anti-Cardiac Antibodies in Cardiomyopathy | |||
Antibody* | Comments | Etiology | Reference |
Anti-B1-adrenergic receptor | cardiomyocyte apoptosis | DCM | Staudt et al.24 |
agonist/antagonist effect, cell surface | DCM | Limas et al.20 | |
Anti-M2-receptor | agonist/antagonist effect | DCM | Fu et al.34 |
Anti-troponin I | Increased expression in sera | ICM/DCM | Doesch et al.28 |
------ | Myocarditis | Kaya et al.3 | |
------ | DCM | Okazaki et al.30 | |
Anti-myosin | ------ | Myocarditis | Neu et al.29 |
cardiomyocyte impaired contractility | DCM | Warraich et al.32 | |
Anti-Na+/K+-ATPase | agonist/antagonist effect, electrical instability | DCM | Baba et al.26 |
Anti-Kv channel | cardiomyocyte cell death | DCM/rat | Landsberger et al.27 |
Anti-mitochondrial | M7, inner mitochondrial membrane | DCM | Klein et al.35 |
Anti-actin | Increased expression in sera | DCM/ICM | Latif et al.36 |
Anti-HSP-60 | abnormal localization to cell surface | DCM/ICM | Lin et al.37 |
*Other anti-cardiac reported in the literature include: anti-SR-Ca2+ATPase, anti-laminin, adenine-nucleotide transporter, anti-tropomyosin.
DCM: dilated cardiomyopathy; ICM: ischemic cardiomyopathy; HSP: heat shock protein.