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. 2013 Mar 11;210(3):563–579. doi: 10.1084/jem.20120662

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© 2013 Anderberg et al.

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Figure 6. — Reduced endoglin expression gives rise to hallmarks of EndMT in tumors in vivo. (a) Immunostaining for CD31 of PNETs from 12-wk-old RIP1-Tag2;Eng^+/+ and RIP1-Tag2;Eng^+/− mice. The dashed line marks the tumor-exocrine pancreas boundary. (b) Quantification of vessels with high CD31 expression in PNET lesions from RIP1-Tag2;Eng^+/+ (n = 3) and RIP1-Tag2;Eng^+/− (n = 4) mice. (c and d) Immunostaining for podocalyxin and CD31 of PNET lesions from 12-wk-old RIP1-Tag2;Eng^+/+ and RIP1-Tag2;Eng^+/− mice. (e) Immunostaining for podocalyxin and α-SMA of PNET lesions from RIP1-Tag2;Eng^+/+ and RIP1-Tag2;Eng^+/− mice. (f) Representative confocal micrograph of immunostaining for CD31 and α-SMA of PNET lesion from 12-wk-old RIP1-Tag2;Eng^+/+ and RIP1-Tag2;Eng^+/− mice. (g) Immunostaining and quantification of NG2 and CD31 of sections of PNET from 12-wk-old RIP1-Tag2 mice. (a, e, and g) Cell nuclei are shown with DAPI. (h) Immunostaining for podocalyxin and α-SMA of EO771 tumors grown in Eng^+/+ or Eng^+/− mice.(i) Quantification of α-SMA⁺ vessels in EO771 tumors from Eng^+/+ (n = 4) and Eng^+/− (n = 4) mice. Error bars depict SD. Bars: (a) Bars, 100 µm; (c–h) 50 µm.