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. 2013 Mar 11;210(3):605–621. doi: 10.1084/jem.20121229

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© 2013 Schürch et al.

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Figure 2. — Immunoediting of LSCs by endogenous CD8⁺ T cells in vivo. (A) ³H-thymidine assay. 3 × 10³ FACS-purified, irradiated (10 Gy) LSC stimulators from H8 CML mice (LSCs) or from CD8-depleted H8 CML mice (αCD8 LSCs) were co-incubated with 1.5 × 10⁴ MACS-purified CD8⁺ T cell responders from naive p14 TCR transgenic animals. Pooled data from two independent experiments are shown. (B and C) 2 × 10⁴ FACS-purified LSCs (solid line, n = 9) or αCD8 LSCs (dotted line, n = 10) were secondarily transplanted into irradiated (6.5 Gy) BL/6 recipient mice. (B) Numbers of BCR/ABL-GFP⁺ granulocytes/µl blood and (C) Kaplan-Meier-survival curves resulting from secondary transplantations. One representative out of three independent experiments is shown. Data are displayed as mean ± SEM. Statistics: Student’s t test (A), two-way ANOVA (B), and log-rank test (C). **, P < 0.005; ***, P < 0.0001. Resp., responders; Stim., stimulators.