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. 2013 Mar 11;210(3):605–621. doi: 10.1084/jem.20121229

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© 2013 Schürch et al.

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Figure 7. — CML treatment with CTLs specific for a ubiquitously expressed antigen increases LSC numbers. (A) Experimental design. 2 × 10⁴ H8 LSCs were FACS-purified 20 d after transplantation and were transferred i.v. into irradiated (6.5 Gy) secondary H8 hosts. 18 h later, mice were either left untreated (Ø, n = 15) or treated with 3 × 10⁶ FACS-purified p14 (n = 16) or p14xIFN-γ^−/− (n = 11) CTLs i.v. After 48 h, BM was harvested and analyzed for BCR/ABL-GFP⁺ cells (B) and LSCs (C) by FACS. (D) In one experiment, serum IFN-y levels were determined 48 h after CTL transfer (n = 4–7 mice per group). (B and C) Pooled data from four independent experiments are shown. Data are displayed as mean ± SEM. Statistics: one-way ANOVA (B and C). ***, P < 0.0001.