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. 2013 Mar 11;210(3):517–534. doi: 10.1084/jem.20120572

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Figure 9. — SPTBN1 affects macrophage susceptibility to HIV-1 infection independently of SAMHD1. (A) Whole-cell lysates of monocytes, M-Mac, and I-Mac (donor 1–3) or whole-cell lysates of monocytes and macrophages (donor 4 and 5) were analyzed for protein expression levels of SPTBN1. GAPDH served as an internal loading control. (B) Macrophages were infected with SIV-GFP after transfection with control siRNA or SPTBN1 specific siRNA (50 pmol). A representative field of macrophages for SIV-GFP expression was shown. Bars, 200 µm. (C) SIV p27 level in culture supernatants was measured. Data shown represent means ± SD of triplicate infection samples.