Table 3.
Prevalence of laboratory abnormalities among COPD cases and controls
| Test | No tests obtained | One or more tests-all normal | One or more tests-at least one elevated | |
|---|---|---|---|---|
| Liver function tests | ||||
| Alkaline phosphatase | COPD | *311 (13.6) | *1659 (72.6) | *314 (13.7) |
| (>Upper limit nl) | Control | 1292 (21.7) | 4104 (68.9) | 563 (9.45) |
| Alkaline phosphatase | COPD | *311 (13.6) | *1929 (84.5) | 44 (1.9) |
| (>2 × Upper limit nl) | Control | 1292 (21.7) | 4572 (76.7) | 95 (1.6) |
| ALT (SGPT) | COPD | *326 (14.3) | *1757 (76.9) | *201 (8.8) |
| (>Upper limit nl) | Control | 1227 (20.6) | 4392 (73.7) | 340 (5.7) |
| ALT (SGPT) | COPD | *326 (14.3) | *1886 (82.6) | *72 (3.2) |
| (>2 × Upper limit nl) | Control | 1227 (20.6) | 4622 (77.6) | 110 (1.8) |
| AST (SGOT) | COPD | *300 (13.1) | *1707 (74.7) | *277 (12.1) |
| (>Upper limit nl) | Control | 1235 (20.7) | 4313 (72.4) | 411 (6.90) |
| AST (SGOT) | COPD | *300 (13.1) | *1880 (82.3) | *104 (4.5) |
| (>2 × Upper limit nl) | Control | 1235 (20.7) | 4563 (76.6) | 161 (2.7) |
| Total bilirubin | COPD | *308 (13.2) | *1725 (75.5) | *251 (11.0) |
| (>Upper limit nl) | Control | 1294 (21.7) | 4165 (69.9) | 500 (8.39) |
| Total bilirubin | COPD | *308 (13.2) | *1924 (84.2) | †52 (2.3) |
| (>2 × Upper limit nl) | Control | 1294 (21.7) | 4575 (76.8) | 90 (1.5) |
| LDH | COPD | *2132 (93.9) | *97 (4.2) | *55 (2.4) |
| (>Upper limit nl) | Control | 5779 (97.0) | 124 (2.0) | 56 (0.9) |
| LDH | COPD | *2132 (93.9) | *146 (6.4) | 6 (0.2) |
| (>2 × Upper limit nl) | Control | 5779 (97.0) | 161 (2.7) | 19 (0.3) |
| Amylase | COPD | *1410 (61.7) | *799 (35.0) | *75 (3.3) |
| (>Upper limit nl) | Control | 4678 (78.5) | 1187 (19.9) | 94 (1.6) |
| Amylase | COPD | *1410 (61.7) | *848 (37.1) | 26 (1.1) |
| (>2 × Upper limit nl) | Control | 4678 (78.5) | 1249 (20.9) | 32 (0.5) |
| Renal function tests | ||||
| Blood urea nitrogen | COPD | *237 (10.4) | *1395 (61.1) | *652 (28.5) |
| (>Upper limit nl) | Control | 1044 (17.5) | 3970 (66.2) | 945 (15.8) |
| Blood urea nitrogen | COPD | *237 (10.4) | *1895 (83.0) | *152 (6.7) |
| (>2 × Upper limit nl) | Control | 1044 (17.5) | 4762 (79.9) | 153 (2.6) |
| Creatinine | COPD | *221 (9.68) | *1445 (63.3) | *618 (27.1) |
| (>Upper limit nl) | Control | 954 (16.0) | 4008 (67.3) | 997 (16.7) |
| Creatinine | COPD | *221 (9.68) | *1946 (85.2) | *117 (5.1) |
| (>2 × Upper limit nl) | Control | 954 (16.0) | 4878 (81.9) | 127 (2.1) |
Notes: Values expressed as the number of patients and row percent of the COPD or control group.
*
Difference between COPD and control significant (P < 0.01).
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; COPD, chronic obstructive pulmonary disease; ULN, upper limit of normal; LDH, lactate dehydrogenase; SGOT, serum glutamic oxaloacetic transaminase; SPGT, serum glutamic pyruvate transaminase.