Table 1.
Ca2+ dependence of neurotransmitter release evoked by different secretogogues. Data shown as mean (sd) (n). Ca2+ dependence was determined as the percentage of the mean normalized sum ΔFR in the absence of Ca2+ compared to that in the presence of Ca2+. ND, not determined. *P<0.05, ***P<0.001 vs glutamate; †††P<0.001 vs GABA; ‡‡‡ P<0.001 vs norepinephrine, by one-way anova with the Tukey post hoc test
| Neurotransmitter | 100 μM 4AP (%) | 1.0 mM 4AP (%) | 15 mM KCl (%) |
|---|---|---|---|
| Glutamate | 68 (6) (9) | 59 (11) (33) | 42 (12) (9) |
| GABA | 78 (3) (9)*** | 72 (6) (33)*** | 56 (12) (9)* |
| Acetylcholine | 97 (5) (6)***,††† | ND | 90 (5) (6)***,††† |
| Norepinephrine | 90 (2) (6)***,††† | 81 (6) (8)***,††† | 90 (5) (6)***,††† |
| Dopamine | 91 (5) (6)***,††† | 37 (9) (10)***,†††,‡‡‡ | 86 (10) (6)***,††† |