Table 3.
Mild cognitive impairment (MCI) or dementia among older women according to hypoxia, sleep fragmentation, or sleep duration measures
| No. (%) with MCI/dementia | Unadjusted OR (95% CI) | Adjusted OR (95% CI)a | |
|---|---|---|---|
| Hypoxia/Disordered Breathing Measures | |||
| Oxygen Desaturation Index | |||
| <15 events/hr | 46 (43.4) | 1.00 | 1.00 |
| ≥15 events/hr | 60 (56.6) | 1.67 (1.03, 2.69) | 1.71 (1.04, 2.83) |
| Sleep time with SaO2 < 90% | |||
| < 1% sleep time | 64 (59.8) | 1.00 | 1.00 |
| ≥1% sleep time | 43 (40.2) | 0.87 (0.54, 1.41) | 0.83 (0.51, 1.38) |
| Sleep time in apnea/hypopnea (%), tertileb | |||
| Low (0.9, 0.0-2.2) | 31 (29.0) | 1.00 | 1.00 |
| Mid (4.4, 2.3-7.0) | 31 (29.0) | 1.00 (0.55, 1.82) | 1.16 (0.61, 2.20) |
| High (16.4, 7.0-66.8) | 45 (42.1) | 1.79 (1.01, 3.20) | 2.04 (1.10, 3.78) |
| Sleep Fragmentation Measures | |||
| Arousal Index (arousals/hour), tertile | |||
| Low (10.1, 2.4-14.5) | 44 (41.5) | 1.00 | 1.00 |
| Mid (18.2, 14.6-22.6) | 30 (28.3) | 0.52 (0.29, 0.94) | 0.54 (0.29, 0.98) |
| High (33.1, 22.6-66.4) | 32 (30.2) | 0.59 (0.34, 1.06) | 0.58 (0.32, 1.07) |
| Wake after sleep onset (minutes), tertile | |||
| Low (40.7, 2.0-61.0) | 31 (29.0) | 1.00 | 1.00 |
| Mid (82.0, 62.0-105.0) | 32 (29.9) | 1.06 (0.58, 1.94) | 1.17 (0.63, 2.19) |
| High (170.6, 108.0-336.0) | 44 (41.1) | 1.69 (0.95, 3.02) | 1.79 (0.97, 3.29) |
| Sleep Duration Measure | |||
| Total sleep time (minutes), tertile | |||
| Low (269.9, 128.0-330.0) | 41 (38.3) | 1.00 | 1.00 |
| Mid (358.2, 331.0-385.0) | 29 (27.1) | 0.56 (0.31, 1.01) | 0.58 (0.31, 1.09) |
| High (425.5, 386.0-630.0) | 37 (34.6) | 0.83 (0.47, 1.47) | 0.83 (0.46, 1.51) |
Abbreviations: OR = Odds ratio; CI = Confidence Interval
a
Adjusted for age, race, body mass index, education, smoking, diabetes, hypertension, antidepressant use, benzodiazepine use, and non-benzodiazepine anxiolytics use
b
(median, range)