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. Author manuscript; available in PMC: 2013 Mar 18.
Published in final edited form as: Gastroenterology. 2008 Sep 25;136(3):1025–1036. doi: 10.1053/j.gastro.2008.09.026

Figure 6.

Figure 6

Effect of SAMe treatment on MAT1A, APEX1, and c-MYC mRNA levels in human cultured hepatocytes. Human hepatocytes were treated with SAMe (2 mmol/L) for different time points. At the indicated time points, RNA from hepatocytes received in suspension (To) or cultured hepatocytes were extracted for real-time PCR. (A) Effect of SAMe treatment on MAT1A mRNA levels. Results are expressed as fold over To cells (mean ± SEM) from 3 independent donors. *P < .03 vs To, **P < .001 vs To, †P < .004 vs UT at respective time points, ‡P < .001 vs UT at respective time points. (B) Effect of SAMe treatment on APEX1 mRNA levels. Results are expressed as fold over To cells (mean ± SEM) from 3 independent donors. *P < .02 vs To, **P < .004 vs To, †P < .02 vs UT at respective time points. (C) Effect of SAMe treatment on c-MYC mRNA levels. Results are expressed as fold over To cells (mean ± SEM) from 3 independent donors. *P < .001 vs To, †P < .02 vs UT at respective time points, ‡P < .001 vs UT at respective time points.