Table 1.

Study treatment doses

	Phase A	Phase B
XELOX	Oxaliplatin: 130 mg/m2 iv day 1
Every 3 weeks	Capecitabine: 1000 mg/m2 po twice daily days 1 to 14
	Bevacizumab: 7.5 mg/kg iv day 1
mFOLFOX6	Oxaliplatin: 85 mg/m2 iv day 1
Every 2 weeks	Leucovorin*: 400 mg/m2 iv day 1
	Fluorouracil: 400 mg/m2 iv day 1
	Fluorouracil: 2400 mg/m2 continuous iv infusion over 46 hours day 1
	Bevacizumab: 5.0 mg/kg iv day 1
FOLFIRI		Irinotecan: 180 mg/m2 iv day 1
Every 2 weeks		Leucovorin*: 400 mg/m2 iv day 1
		Fluorouracil: 400 mg/m2 iv day 1
		Fluorouracil: 2400 mg/m2 continuous iv infusion over 46 hours day 1
		Bevacizumab: 5.0 mg/kg iv day 1

* Investigators may elect to use low dose leucovorin i.e. either 20 mg/m² or 50 mg total dose.