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. 2013 Mar 15;8:1155–1165. doi: 10.2147/IJN.S39491

Figure 5.

Figure 5

Fluorescence microscopy of HeLa and HaCaT cells incubated with various liposomal formulations containing FITC-dextran at 37°C and pH 7.4 for 4 hours.

Notes: green fluorescence represents cellular translocation of the probe-entrapped liposomal carrier. While peptide conjugation (P-Lipo) increased translocation into both cells with no difference, folate modification (F- and FP-Lipo) manifested the selectivity to FR-positive HeLa cells, resulting in the greatest uptake of FP-Lipo.

Abbreviations: FITC-dextran, fluorescein dextran isothiocyanate; P-Lipo, Pep-1 peptide–modified liposomes; F-Lipo, folate-modified liposomes; FP-Lipo, dual ligand–modified liposomes; C-Lipo, conventional liposomes.