Evaluation of five types of antiglaucoma PG analog ophthalmic formulations using corneal resistance measuring device (in vivo).
Notes: (A) ▲: latanoprost; (B) •: tafluprost; (C) ×: bimatoprost; (D) □: travoprost; (E) ■: travoprost-Z; *P < 0.05; N = 4, (mean ± SD). CR ratio (%) significantly decreased with latanoprost (82.0%, 2 minutes after instillation) and with travoprost (81.0%, 30 minutes after instillation), but recovered as time advanced (P < 0.05). On the other hand, a decrease in the CR ratio was rarely observed with travoprost-Z. The CR ratio with tafluprost or bimatoprost did not decrease, and tended to be slightly higher after instillation.
Abbreviations: PG, prostaglandin; Cr, corneal resistance; SD, standard deviation.