Table 2. Hemodynamic parameters in PDE5-TG and WT after 10 weeks TAC.
| 10 weeks TAC | ||
| WT (n = 11) | PDE5-TG (n = 18) | |
| HW/BW (mg/g) | 7.2±0.5 | 6.8±0.2 |
| RCA-LCA gradient (mmHg) | 78±11 | 47±5* |
| Maximum pressure (mmHg) | 145±7 | 106±5* |
| dP/dtmax (mmHg/s) | 9811±809 | 5868±375* |
| dP/dtmin (mmHg/s) | −9638±769 | −5989±453* |
| Tau (ms) | 10.9±1.1 | 13.6±1.0* |
| HR (bpm) | 580±29 | 519±22 |
HW/BW indicates heart to body weight ratio; RCA-LCA gradient, gradient between right and left common carotid artery; dP/dtmax and dP/dtmin, maximum and minimum of the first derivative of LV pressure over time; Tau, time constant for isovolumic relaxation (Weiss); and HR, heart rate. *P<0.05 vs WT.