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Figure 1. Cell surface phenotypes in melanoma. On the left (green): cell surface markers associated with melanoma survival. Co-stimulatory molecules: CD27 and CD28; activation markers: CD107a, CD69, CD134 (OX40) and CD25 (IL-2Rα); cytokine receptors that promote T-cell survival: CD25 (IL-2Rα) and IL-7R; memory T-cell markers: CD45RO, CD62L, and CCR7. On right (pink): cell surface markers associated with melanoma progression. Inhibitory receptors, CTLA-4 and PD-1.
