Table 1.
Summary of group demographic, neuropsychological, and CSF data
| n (female) | nv-PPA |
lv-PPA |
sv-PPA |
AD |
Control |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| 13 (10) |
10 (5) |
10 (7) |
20 (11) |
20 (12) |
||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Age | 65.7 | 9.4 | 67.0 | 6.1 | 63.4 | 6.7 | 62.8 | 5.0 | 64.7 | 5.5 |
| Disease duration (years) | 3.3 | 1.2 | 4.0 | 1.4 | 5.0 | 2.0 | 5.6 | 3.8 | — | — |
| Recognition Memory-Words (/50)a | 40.5 | 8.9 | 29.9 | 9.1 | 32.0 | 8.0 | 30.1 | 6.1 | 47.1b | 2.3 |
| MMSE (/30) | 18.0 | 10.9 | 16.9 | 8.5 | 20.6 | 8.5 | 21.0 | 4.6 | 29.6b | 0.5 |
| Recognition Memory-Faces (/50)c | 36.7 | 5.8 | 29.8 | 7.4 | 31.7 | 7.8 | 33.7 | 6.0 | 41.8b | 5.0 |
| BPVS (/150)d | 120.6 | 41.0 | 87.4 | 46.4 | 65.6 | 49.2 | 135.5 | 22.8 | 147.8b | 1.5 |
| Concrete synonyms (/25)b | 18.3 | 4.6 | 17.8 | 5.6 | 14.3 | 6.3 | — | — | 24.5b | 0.7 |
| Graded Naming Test (/30)e | 10.8 | 10.6 | 4.4 | 4.3 | 1.6 | 4.3 | 13.4 | 8.7 | 26.8b | 1.7 |
| Graded Arithmetic Test (/24)f | 4.2 | 2.6 | 0.1 | 0.3 | 8.3 | 8.8 | 5.1 | 4.3 | 12.9g | 4.4 |
| VOSP Object Decision (/20) | 16.5 | 3.1 | 14.6 | 6.2 | 14.6 | 4.3 | 15.7 | 2.5 | 18.0b | 3.5 |
| Stroop Color Naming (s)h | 74.5 | 21.4 | 68.0 | 20.6 | 56.8 | 23.0 | 55.2 | 18.6 | 30.2b | 3.8 |
| Word Repetition (/45)i | 21.8 | 16.0 | 40.3 | 5.1 | 43.9 | 1.4 | — | — | 44.3g | 1.0 |
| Sentence Repetition (/10)j | 3.7 | 3.9 | 6.2 | 3.1 | 9.6 | 0.7 | — | — | 9.8g | 0.6 |
| Receptive Grammar-PALPA 55 (/24) | 16.1 | 7.4 | 11.6 | 6.0 | 21.1 | 3.0 | — | — | 23.5b | 0.7 |
| Baxter Spelling Test (/30) | 11.2 | 9.7 | 6.7 | 5.9 | 14.0 | 10.4 | — | — | 26.9g | 1.3 |
| CSF | n = 7 | n = 9 | n = 5 | n = 10 | ||||||
| CSF Total tau (pg/mL) | 540 | 370 | 888 | 318 | 350 | 131 | 770 | 355 | ||
| CSF ABeta1–42 | 384 | 148 | 256 | 122 | 669 | 156 | 240 | 64 | ||
Number with neuropsychological data: sv-PPA, n = 9; nv-PPA, n = 11; lv-PPA, n = 10. Further background information about behavioral tests is provided in Supplementary data (see “Description of behavioural tests”).
Key: AD, Alzheimer's disease; BPVS, British Picture Vocabulary Scale; CSF, cerebrospinal fluid; lv-PPA, logopenic variant PPA; MMSE, Mini-Metal State Examination; nv-PPA, non-fluent/agrammatic PPA; PALPA, psycholinguistic assessment of language processing in aphasia; PPA, primary progressive aphasia; sv-PPA, semantic variant PPA; VOSP, visual object and space perception test.
p < 0.05 nv-PPA versus AD.
p < 0.05 control versus all disease groups p < 0.05.
p < 0.05 nv-PPA versus lv-PPA and sv-PPA; p < 0.05 lv-PPA versus sv-PPA.
p < 0.05 sv-PPA versus all groups; p < 0.05 lv-PPA versus nv-PPA and AD.
p < 0.05 sv-PPA versus all groups; p < 0.05 lv-PPA versus AD.
p < 0.05 lv-PPA versus all groups.
p < 0.05 control versus nv-PPA and lv-PPA.
p < 0.05 nv-PPA versus AD.
p < 0.05 nv-PPA versus lv-PPA and sv-PPA.
p< 0.05 sv-PPA versus nv-PPA and lv-PPA.