Table 3.
Comparison of fractional anisotropy changes in DTI studies of PPA
| Report | Subjects | Tract selection | Dir | Statistical method | Software | UF |
ILF |
SLF |
Other |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NV | LV | SV | NV | LV | SV | NV | LV | SV | NV | LV | SV | ||||||
| Agosta et al., 2010 | SV = 5; control = 8 | ROI (L ILF/L SLF/L UF/CC) | 55 | Linear mixed effects model | In-house | nt | nt | L | nt | nt | nsr | nt | nt | La | nt | nt | CCb |
| Whitwell et al., 2010 | NV = 7; SV = 4; control = 19 | ROI; n = 16 | 21 | ANCOVA | DTI Studio | nsr | nt | nsr | nsr | nt | Lc | Rd | nt | nsr | nt | nt | nt |
| Galantucci et al., 2011 | NV = 9; LV = 9; SV = 9; control = 21 | ROI (ILF/UF/SLF) | 64 | ANCOVA | PROBTRACKX | nsr | nsr | B | nsr | nsr | Be | L | Lf | Lg | nt | nt | nt |
| Acosta-Cabronero et al., 2011 | SV = 10; control = 21 | Whole brain | 63 | Nonparametric permutation test | FDT/TBSS/Tractography | nt | nt | nsr | nt | nt | Lh | nt | nt | nsr | nt | nt | nt |
| Agosta et al., 2011 | NV = 9; LV = 4; SV = 7; control = 27 | Whole brain | 32 | Nonparametric permutation test | FDT/TBSS | L | nsr | B | Li | nsr | Li | L | nsr | nsr | B CB, CC, FO | FO | CC, L CB, FO |
| Schwindt et al., 2011 | SV = 9; NV = 9; control = 16 | Whole brain | 23 | Nonparametric permutation test | FDT/TBSS | L | nt | B | L | nt | B | nsr | nt | B | nt | nt | L ATR, B FM, CC |
| Present study | NV = 13; LV = 10; SV = 10; AD = 20; control = 20 | Whole brain | 64 | Nonparametric permutation test | CAMINO/TBSS | L | L | B | nsr | L | L | nsr | nsr | nsr | L CST | L CB, FO | L ATR, R CB |
Results reported reflect most statistically robust findings (for present study, only significance values p < 0.01 are included here; see also Table 2).
Key: AD, Alzheimer's disease; ANCOVA, analysis of covariance; ATR, anterior thalamic radiation; B, bilateral; CB, cingulum bundle; CC, corpus callosum; CST, corticospinal tract; Dir, number of diffusion gradient directions used in DTI acquisition; DTI, diffusion tensor imaging; FDT, FMRIB diffusion toolbox; FM, forceps major; FO, fornix; ILF, inferior longitudinal fasciculus; L, left; LV, logopenic variant PPA; nsr, no significant result found; nt, data not reported/tested; NV, nonfluent/agrammatic PPA; PPA, primary progressive aphasia; R, right; ROI, region of interest; SLF, superior longitudinal fasciculus; SV, semantic variant; TBSS, tract based spatial statistics; UF, uncinate fasciculus.
Arcuate and frontoparietal SLF.
Genu.
Posterior ILF.
Anterior SLF.
Bilateral anterior ILF and left medial ILF.
SLF temporoparietal fibers.
Arcuate and SLF temporoparietal.
Results reported based on authors' figures.
Inferior fronto-occipital fasciculus.