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Early treatment initiation: start day 3. Original dosing (top row) and fractionated dosing (bottom row) compared. 5 × 105 B16F10 melanoma cells on day 1, DC injections of 7 × 105, and 21 × 105 are administered both intratumorally and intravenously 0.25 × 105, 1.75 × 105, and 5.25 × 105 twice a day on days 3, 4, 5, 6, 7, 8. Treatment is given both intratumorally (left column) and intravenously (right column).
