Table 1.
Demographics and Baseline Characteristics for Pooled CAP Studies 308 and 313 (Modified Intention to Treat Population)
| Characteristic | Tigecycline(n = 424) | Levofloxacin(n = 422) | p-Value |
|---|---|---|---|
| Age, Years | |||
| Mean | 52.65 | 51.87 | 0.539 |
| SD | 17.99 | 18.74 | |
| Male, n (%) | 243 (57.3) | 265 (62.8) | 0.107 |
| Specific Risk Factors, n (%) | |||
| Aged ≥65 years | 122 (28.8) | 122 (28.9) | 1.000 |
| Prior antibiotic failure | 62 (14.6) | 74 (17.5) | 0.262 |
| Bacteremia | 32 (7.5) | 31 (7.3) | 1.000 |
| Multilobar disease at baseline | 125 (29.5) | 106 (25.1) | 0.165 |
| COPD | 49 (11.6) | 43 (10.2) | 0.581 |
| Hypoxemia | 106 (25.0) | 113 (26.8) | 0.583 |
| Renal insufficiency or BUN >19.6 mg/dL or urea >7 mmol/L | 136 (32.1) | 132 (31.3) | 0.825 |
| Diabetes or glucose >13.9 mmol/L | 56 (13.2) | 61 (14.5) | 0.620 |
| Alcohol abuse | 35 (8.3) | 33 (7.8) | 0.899 |
| Altered mental status | 9 (2.1) | 9 (2.1) | 1.000 |
| WBC count >30 x 109/L or <4 x 109/L | 21 (5.0) | 19 (4.5) | 0.872 |
| CURB-65 Score, n (%) | |||
| Total score ≥2 | 122 (28.8) | 124 (29.4) | 0.880 |
| CURB-65 Score Components | |||
| Confusion (altered mental status from medical history) | 9 (2.1) | 9 (2.1) | 1.000 |
| Urea >7 mmol/L (BUN >19.6 mg/dL) | 129 (30.4) | 125 (29.6) | 0.822 |
| Respiratory rate ≥30 breaths/min | 109 (25.7) | 95 (22.5) | 0.296 |
| Blood pressure <90 systolic or diastolic blood pressure ≤60 | 74 (17.5) | 86 (20.4) | 0.293 |
| Aged ≥65 years | 122 (28.8) | 122 (28.9) | 1.000 |
| Fine Score, n (%) | |||
| Category III-V | 197 (46.5) | 199 (47.2) | 0.890 |
| Clinical Instability Criteria | |||
| At least 2 criteria (listed below), n (%) | 336 (79.2) | 333 (78.9) | 0.933 |
| Oral temperature >37.8°C | 381 (89.9) | 384 (91.0) | 0.641 |
| Heart rate >100 bpm | 168 (39.6) | 171 (40.5) | 0.833 |
| Respiratory rate >24 breaths/min | 166 (39.2) | 157 (37.2) | 0.572 |
| Systolic blood pressure <90 mm Hg | 11 (2.6) | 13 (3.1) | 0.685 |
| Hypoxemia | 106 (25.0) | 113 (26.8) | 0.583 |
| WBC count >11 x 109/L | 231 (54.5) | 235 (55.7) | 0.730 |
| Altered mental status | 9 (2.1) | 9 (2.1) | 1.000 |
COPD: chronic obstructive pulmonary disease; BUN: blood urea nitrogen; WBC: white blood cell.