Table 3.
Mortality Rates by Risk Factor (Modified Intention to Treat Population)
| Risk Factor | Tigecycline, n (%) | Levofloxacin, n (%) |
|---|---|---|
| Overall | 12 (2.8) | 11 (2.6) |
| Aged ≥65 years | 8 (6.6) | 5 (4.1) |
| Prior antibiotic failure | 2 (3.2) | 1 (1.4) |
| Bacteremia | 1 (3.1) | 1 (3.2) |
| Multilobar disease at baseline | 8 (6.4) | 7 (6.6) |
| COPD | 5 (10.2) | 3 (7.0) |
| Hypoxemia | 4 (3.8) | 5 (4.4) |
| Renal insufficiency or BUN >19.6 mg/dL or urea >7 mmol/L | 4 (2.9) | 4 (3.0) |
| Diabetes or glucose >13.9 mmol/L | 1 (1.8) | 2 (3.3) |
| Alcohol abuse | 1 (2.9) | 2 (6.1) |
| Altered mental status | 2 (22.2) | 0 |
| WBC count >30 x 109/L or <4 x 109/L | 1 (4.8) | 1 (5.3) |
| Higher risk of mortality | 12 (4.1) | 10 (3.7) |
CE: clinically evaluable; c-mITT: clinical modified intention to treat; COPD: chronic obstructive pulmonary disease; BUN: blood urea nitrogen; WBC: white blood cell.