Fig. (5).

A naive model STPK activation mediated by muropeptides. Left: muropeptides bind to PASTA3 on the PrkC sensor domain [89]. Right: muropeptide binding bridge protein-protein interaction and brings the intracellular kinase domains close enough to allow for their dimerization. The model of the entire STPK is based on the crystal structures of PrkC sensor from S. aureus (PDB code 3PY9) and of PknB kinase domain (PDB code 3F69). The muropeptide interaction site on the PASTA3 domain of the PrkC sensor region is based on Squeglia et. al [89].