Table 2.
Expression of Neuropeptide-Specific Receptors on Immune and Non-Immune Cells.
| CELLS | NEUROPEPTIDES | RECEPTORS | References |
|---|---|---|---|
| Neutrophils | NPY | Y1 | [43] |
| Y2 | [43] | ||
| Y4 | [43] | ||
| Y5 | [43] | ||
| SP | NK1R | [126] | |
| VIP/PACAP | VPAC1 | [127] | |
| α-MSH | MC-1 | [128] | |
| Monocytes | NPY | Y2 | [129] |
| SP | NK1R | [130] | |
| AM | CRLR-RAMP2 | [131] | |
| CRLR-RAMP3 | [131] | ||
| VIP/PACAP | VPAC1 | [132, 133] | |
| VPAC2 | [133, 134] | ||
| PAC1 | [133] | ||
| α-MSH | MC-1 | [135, 136] | |
| MC-3 | [137] | ||
| MC-5 | [137] | ||
| Macrophages | NPY | Y1 | [138] |
| SP | NK-1R | [130] | |
| AM | CRLR-RAMP2 | [131] | |
| CRLR-RAMP3 | [131] | ||
| CGRP | CGRP-R | [139] | |
| VIP/PACAP | VPAC1 | [140] | |
| VPAC2 | [141, 142] | ||
| PAC1 | [143] | ||
| α-MSH | MC-1 | [144, 145] | |
| Lymphocytes B | SP | NK1R | [146] |
| α-MSH | MC-1 | [145] | |
| Lymphocytes T | SP | NK1R | [147] |
| AM | CRLR-RAMP2 | [131] | |
| CRLR-RAMP3 | [131] | ||
| CGRP | CGRP-R | [148] | |
| VIP/PACAP | VPAC1 | [132] | |
| VPAC2 | [132] | ||
| α-MSH | MC-1 | [145] | |
| Eosinophils | VIP/PACAP | VPAC1 | [149] |
| Mast cells | SP | NK1R | [57, 150] |
| NK2R | [57] | ||
| NK3R | [57] | ||
| VIP/PACAP | VPAC1 | [151] | |
| VPAC2 | [57, 151] | ||
| α-MSH | MC-1 | [152] | |
| Dendritic cells | SP | NK-1R | [153] |
| AM | CRLR-RAMP2 | [131] | |
| CRLR-RAMP3 | [131] | ||
| CGRP | CGRP-R | [154] | |
| VIP/PACAP | VPAC1 | [131] | |
| α-MSH | MC-1 | [155] | |
| Natural killers | SP | NK1R | [156] |
| α-MSH | MC-1 | [145] | |
| Fibroblasts | NPY | Y1 | [65] |
| SP | NK1R | [157] | |
| AM | L1-R | [158] | |
| Keratinocytes | SP | NK1R | [157] |
| AM | L1-R | [158] | |
| VIP/PACAP | VPAC1 | [159, 160] | |
| VPAC2 | [159, 160] |