Scheme 2. Synthesis of Benzo[b]thiophene 9.
Reagents and conditions: (a) ethyl bromoacetate, t-BuOK, THF, rt, 15 min, 88%; (b) 1-Boc-4-piperidinol, diisopropyl azodicarboxylate, PPh3, THF, rt, 1.5 h, 97%; (c) 10% TFA in DCM (v/v), rt, 2 h, 82%.
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