Table 5.

The Observed and Predicted Values of the Particle Size, Drug Loading, and Burst Release for SAR 1118-Encapsulated PLGA (85:15), PLGA (75:25), and PLGA (50:50) Microspheres Prepared Using Optimized Parameters Based on Box-Behnken Design

	Predicted value			Actual value
Formulation	Drug loading (%w/w)	Burst release (%)	Particle size (μm)	Drug loading (%w/w)	Burst release (%)	Particle size (μm)
PLGA(85:15)	20.23	13.55	2.41	18.35±0.3	15.87±1.1	2.74±0.6
PLGA(75:25)	18.89	14.47	2.28	16.86±2.6	13.73±1.2	2.12±0.8
PLGA(50:50)	15.89	17.58	2.38	14.92±3.0	20.09±0.3	2.20±0.6

PLGA, poly (lactide-co-glycolide).