Figure 2.

A, Genetic map of the CXCR6 gene region. CXCR6 is localized within the 14th intron of a predicted gene, FYCO1. B, Genetic map of the CXCR6 gene. Exons and untranslated regions are symbolized by full and empty rectangles, respectively. The positions of the ATG and STOP codons are indicated by a triangle (▸) and an asterisk (^*), respectively. All single-nucleotide polymorphisms (SNPs) covered by the polymerase chain reaction sequencing study are represented, and the rs2234358 SNP of interest is shown in boldface type. The 3 promoter haplotypes in high linkage disequilibrium (LD) with rs2234358 (r² = 0.97) correspond to 2-SNP haplotypes composed of the rs2234350 SNP (°), with either one of the SNPs denoted by the + symbol (these 3 latter SNPs exhibit r² = 0.99).