Table 1.
A summary of significant NMR-single traits and classical lipids SNPs associations tagging proxy genes, with details analogous to the ones produced in Supplemental Tables 2–20
| No GENE | TOTAL LDL | LARGE LDL | SMALL LDL | LDL SIZE | TOTAL HDL | LARGE HDL | MEDIUM HDL | SMALL HDL | HDL SIZE | TOTAL VLDL | LARGE VLDL | MEDIUM VLDL | SMALL VLDL | VLDL SIZE | IDL | CHYL | TG | HDLC | LDLC | GeneName | Position | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ABCC11 | D | ATP-binding cassette, sub-family C (CFTR/MRP), member 11 | chr16:q12.1 | ||||||||||||||||||
| 2 | ABCC12 | D | ATP-binding cassette, sub-family C (CFTR/MRP), member 12 | chr16:q12.1 | ||||||||||||||||||
| 3 | ACOXL | C | C | acyl-CoA oxidase-like | chr2:q13 | |||||||||||||||||
| 4 | ADARB2 | B | adenosine deaminase, RNA-specific, B2 | chr10:p15.3 | ||||||||||||||||||
| 5 | APOB | A, C, F | apolipoprotein B (including Ag(x) antigen) | chr2:p24.1 | ||||||||||||||||||
| 6 | ASPSCR1 | D | alveolar soft part sarcoma chromosome region, candidate 1 | chr17:q25.3 | ||||||||||||||||||
| 7 | ATP6V1G1 | E | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | chr9:q32 | ||||||||||||||||||
| 8 | B3GAT2 | D, F | D, E, F | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) | chr6:q13 | |||||||||||||||||
| 9 | BCL2L11 | C | C | BCL2-like 11 (apoptosis facilitator) | chr2:q13 | |||||||||||||||||
| 10 | BTG4 | B, C | A | B-cell translocation gene 4 | chr11:q23.1 | |||||||||||||||||
| 11 | BZW2 | E, F | basic leucine zipper and W2 domains 2 | chr7:p21.1 | ||||||||||||||||||
| 12 | C10ORF47 | F | chromosome 10 open reading frame 47 | chr10:p14 | ||||||||||||||||||
| 13 | C14ORF177 | F | chromosome 14 open reading frame 177 | chr14:q32.2 | ||||||||||||||||||
| 14 | C1ORF174 | D | D | chromosome 1 open reading frame 174 | chr1:p36.32 | |||||||||||||||||
| 15 | C1ORF52 | F | chromosome 1 open reading frame 52 | chr1:p22.3 | ||||||||||||||||||
| 16 | C5ORF48 | F | chromosome 5 open reading frame 48 | chr5:q23.2 | ||||||||||||||||||
| 17 | C9ORF79 | B | chromosome 9 open reading frame 79 | chr9:q22.1 | ||||||||||||||||||
| 18 | CACNG3 | A, B | A | calcium channel, voltage-dependent, gamma subunit 3 | chr16:p12.1 | |||||||||||||||||
| 19 | CBLN4 | B, C, E | F | B, C, E | cerebellin 4 precursor | chr20:q13.2 | ||||||||||||||||
| 20 | CCDC41 | E | coiled-coil domain containing 41 | chr12:q22 | ||||||||||||||||||
| 21 | CCDC79 | D | coiled-coil domain containing 79 | chr16:q22.1 | ||||||||||||||||||
| 22 | CDH4 | E | cadherin 4, type 1, R-cadherin (retinal) | chr20:q13.33 | ||||||||||||||||||
| 23 | CDH8 | E | cadherin 8, type 2 | chr16:q21 | ||||||||||||||||||
| 24 | CDKAL1 | B, F | CDK5 regulatory subunit associated protein 1-like 1 | chr6:p22.3 | ||||||||||||||||||
| 25 | CETP | A, D | cholesteryl ester transfer protein, plasma | chr16:q13 | ||||||||||||||||||
| 26 | COL27A1 | B | collagen, type XXVII, alpha 1 | chr9:q32 | ||||||||||||||||||
| 27 | CPEB2 | D | cytoplasmic polyadenylation element binding protein 2 | chr4:4p15.33 | ||||||||||||||||||
| 28 | CPNE4 | F | F | copine IV | chr3:q22.1 | |||||||||||||||||
| 29 | CSMD1 | F | CUB and Sushi multiple domains 1 | chr8:p23.2 | ||||||||||||||||||
| 30 | CRIPT | A, C | cysteine-rich PDZ-binding protein | chr2:p21 | ||||||||||||||||||
| 31 | DEFB119 | F | F | F | defensin, beta 119 | chr20:q11.21 | ||||||||||||||||
| 32 | DEFB123 | F | F | F | defensin, beta 123 | chr20:q11.21 | ||||||||||||||||
| 33 | DEFB133 | B | defensin, beta 133 | chr6:p12.3 | ||||||||||||||||||
| 34 | DISC1 | B, C | disrupted in schizophrenia 1 | chr1:q42.2 | ||||||||||||||||||
| 35 | DYNC1LI2 | D | dynein, cytoplasmic 1, light intermediate chain 2 | chr16:q22.1 | ||||||||||||||||||
| 36 | EEPD1 | A | A | endonuclease/exonuclease/phosphatase family domain containing 1 | chr7:p14.2 | |||||||||||||||||
| 37 | EFCAB4B | E | E, F | EF-hand calcium binding domain 4B | chr12:p13.32 | |||||||||||||||||
| 38 | EGLN3 | C | C | egl nine homolog 3 (C. elegans) | chr14:q13.1 | |||||||||||||||||
| 39 | EMCN | E | endomucin | chr4:q24 | ||||||||||||||||||
| 40 | FAM167A | F | family with sequence similarity 167, member A | chr8:p23.1 | ||||||||||||||||||
| 41 | FAM63B | B | family with sequence similarity 63, member B | chr15:q21.3 | ||||||||||||||||||
| 42 | FAM84B | A, B, C | A | A | family with sequence similarity 84, member B | chr8:q24.21 | ||||||||||||||||
| 43 | FLRT2 | F | fibronectin leucine rich transmembrane protein 2 | chr14:q31.3 | ||||||||||||||||||
| 44 | FSHR | B, F | follicle stimulating hormone receptor | chr2:p16.3 | ||||||||||||||||||
| 45 | FTMT | A | ferritin mitochondrial | chr5:q23.1 | ||||||||||||||||||
| 46 | GDF10 | D | growth differentiation factor 10 | chr10:q11.22 | ||||||||||||||||||
| 47 | GDF2 | D | growth differentiation factor 2 | chr10:q11.22 | ||||||||||||||||||
| 48 | GLI3 | E | GLI family zinc finger 3 | chr7:p14.1 | ||||||||||||||||||
| 49 | GPR133 | C | B, C | C | G protein-coupled receptor 133 | chr12:q24.33 | ||||||||||||||||
| 50 | HAAO | F | 3-hydroxyanthranilate 3,4-dioxygenase | chr2:p21 | ||||||||||||||||||
| 51 | HOMER1 | A, B, C | A | homer homolog 1 (Drosophila) | chr5:q14.1 | |||||||||||||||||
| 52 | IQCJ-SCHIP1 | D | IQ motif containing J-schwannomin interacting protein 1 fusion protein | chr3 | ||||||||||||||||||
| 53 | KIAA1217 | F | KIAA1217 | chr10:p12.2 | ||||||||||||||||||
| 54 | KIT | A, D | A, D | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | chr4:q12 | |||||||||||||||||
| 55 | KRTAP5-6 | A | D | keratin associated protein 5-6 | chr11:p15.5 | |||||||||||||||||
| 56 | LIPC | A | lipase, hepatic | chr15:q21.3 | ||||||||||||||||||
| 57 | LMO7 | E | E | LIM domain 7 | chr13:q22.2 | |||||||||||||||||
| 58 | LOC100129636 | F | NA | chr6:p22.1 | ||||||||||||||||||
| 59 | LOC100132713 | E | NA | chr18:q23 | ||||||||||||||||||
| 1 | ABCC11 | D | ATP-binding cassette, sub-family C (CFTR/MRP), member 11 | chr16:q12.1 | ||||||||||||||||||
| 2 | ABCC12 | D | ATP-binding cassette, sub-family C (CFTR/MRP), member 12 | chr16:q12.1 | ||||||||||||||||||
| 3 | ACOXL | C | C | acyl-CoA oxidase-like | chr2:q13 | |||||||||||||||||
| 4 | ADARB2 | B | adenosine deaminase, RNA-specific, B2 | chr10:p15.3 | ||||||||||||||||||
| 5 | APOB | A, C, F | apolipoprotein B (including Ag(x) antigen) | chr2:p24.1 | ||||||||||||||||||
| 6 | ASPSCR1 | D | alveolar soft part sarcoma chromosome region, candidate 1 | chr17:q25.3 | ||||||||||||||||||
| 7 | ATP6V1G1 | E | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | chr9:q32 | ||||||||||||||||||
| 8 | B3GAT2 | D, F | D, E, F | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) | chr6:q13 | |||||||||||||||||
| 9 | BCL2L11 | C | C | BCL2-like 11 (apoptosis facilitator) | chr2:q13 | |||||||||||||||||
| 10 | BTG4 | B, C | A | B-cell translocation gene 4 | chr11:q23.1 | |||||||||||||||||
| 11 | BZW2 | E, F | basic leucine zipper and W2 domains 2 | chr7:p21.1 | ||||||||||||||||||
| 12 | C10ORF47 | F | chromosome 10 open reading frame 47 | chr10:p14 | ||||||||||||||||||
| 13 | C14ORF177 | F | chromosome 14 open reading frame 177 | chr14:q32.2 | ||||||||||||||||||
| 14 | C1ORF174 | D | D | chromosome 1 open reading frame 174 | chr1:p36.32 | |||||||||||||||||
| 15 | C1ORF52 | F | chromosome 1 open reading frame 52 | chr1:p22.3 | ||||||||||||||||||
| 16 | C5ORF48 | F | chromosome 5 open reading frame 48 | chr5:q23.2 | ||||||||||||||||||
| 17 | C9ORF79 | B | chromosome 9 open reading frame 79 | chr9:q22.1 | ||||||||||||||||||
| 18 | CACNG3 | A, B | A | calcium channel, voltage-dependent, gamma subunit 3 | chr16:p12.1 | |||||||||||||||||
| 19 | CBLN4 | B, C, E | F | B, C, E | cerebellin 4 precursor | chr20:q13.2 | ||||||||||||||||
| 20 | CCDC41 | E | coiled-coil domain containing 41 | chr12:q22 | ||||||||||||||||||
| 21 | CCDC79 | D | coiled-coil domain containing 79 | chr16:q22.1 | ||||||||||||||||||
| 22 | CDH4 | E | cadherin 4, type 1, R-cadherin (retinal) | chr20:q13.33 | ||||||||||||||||||
| 23 | CDH8 | E | cadherin 8, type 2 | chr16:q21 | ||||||||||||||||||
| 24 | CDKAL1 | B, F | CDK5 regulatory subunit associated protein 1-1ike 1 | chr6:p22.3 | ||||||||||||||||||
| 25 | CETP | A, D | cholesteryl ester transfer protein, plasma | chr16:q13 | ||||||||||||||||||
| 26 | COL27A1 | B | collagen, type XXVII, alpha 1 | chr9:q32 | ||||||||||||||||||
| 27 | CPEB2 | D | cytoplasmic polyadenylation element binding protein 2 | chr4:4p15.33 | ||||||||||||||||||
| 28 | CPNE4 | F | F | copine IV | chr3:q22.1 | |||||||||||||||||
| 29 | CSMD1 | F | CUB and Sushi multiple domains 1 | chr8:p23.2 | ||||||||||||||||||
| 30 | CRIPT | A, C | cysteine-rich PDZ-binding protein | chr2:p21 | ||||||||||||||||||
| 31 | DEFB119 | F | F | F | defensin, beta 119 | chr20:q11.21 | ||||||||||||||||
| 32 | DEFB123 | F | F | F | defensin, beta 123 | chr20:q11.21 | ||||||||||||||||
| 33 | DEFB133 | B | defensin, beta 133 | chr6:p12.3 | ||||||||||||||||||
| 34 | DISC1 | B, C | disrupted in schizophrenia 1 | chr1:q42.2 | ||||||||||||||||||
| 35 | DYNC1LI2 | D | dynein, cytoplasmic 1, light intermediate chain 2 | chr16:q22.1 | ||||||||||||||||||
| 36 | EEPD1 | A | A | endonuclease/exonuclease/phosphatase family domain containing 1 | chr7:p14.2 | |||||||||||||||||
| 37 | EFCAB4B | E | E, F | EF-hand calcium binding domain 4B | chr12:p13.32 | |||||||||||||||||
| 38 | EGLN3 | C | C | egl nine homolog 3 (C. elegans) | chr14:q13.1 | |||||||||||||||||
| 39 | EMCN | E | endomucin | chr4:q24 | ||||||||||||||||||
| 40 | FAM167A | F | family with sequence similarity 167, member A | chr8:p23.1 | ||||||||||||||||||
| 41 | FAM63B | B | family with sequence similarity 63, member B | chr15:q21.3 | ||||||||||||||||||
| 42 | FAM84B | A, B, C | A | A | family with sequence similarity 84, member B | chr8:q24.21 | ||||||||||||||||
| 43 | FLRT2 | F | fibronectin leucine rich transmembrane protein 2 | chr14:q31.3 | ||||||||||||||||||
| 44 | FSHR | B, F | follicle stimulating hormone receptor | chr2:p16.3 | ||||||||||||||||||
| 45 | FTMT | A | ferritin mitochondrial | chr5:q23.1 | ||||||||||||||||||
| 46 | GDF10 | D | growth differentiation factor 10 | chr10:q11.22 | ||||||||||||||||||
| 47 | GDF2 | D | growth differentiation factor 2 | chr10:q11.22 | ||||||||||||||||||
| 48 | GLI3 | E | GLI family zinc finger 3 | chr7:p14.1 | ||||||||||||||||||
| 49 | GPR133 | C | B, C | C | G protein-coupled receptor 133 | chr12:q24.33 | ||||||||||||||||
| 50 | HAAO | F | 3-hydroxyanthranilate 3,4-dioxygenase | chr2:p21 | ||||||||||||||||||
| 51 | HOMER1 | A, B, C | A | homer homolog 1 (Drosophila) | chr5:q14.1 | |||||||||||||||||
| 52 | IQCJ-SCHIP1 | D | IQ motif containing J-schwannomin interacting protein 1 fusion protein | chr3 | ||||||||||||||||||
| 53 | KIAA1217 | F | KIAA1217 | chr10:p12.2 | ||||||||||||||||||
| 54 | KIT | A, D | A, D | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | chr4:q12 | |||||||||||||||||
| 55 | KRTAP5-6 | A | D | keratin associated protein 5-6 | chr11:p15.5 | |||||||||||||||||
| 56 | LIPC | A | lipase, hepatic | chr15:q21.3 | ||||||||||||||||||
| 57 | LMO7 | E | E | LIM domain 7 | chr13:q22.2 | |||||||||||||||||
| 58 | LOC100129636 | F | NA | chr6:p22.1 | ||||||||||||||||||
| 59 | LOC100132713 | E | NA | chr18:q23 | ||||||||||||||||||
A–F letters used in Table 1 point to results corresponding to the following times, visit 2 blood draw 1, v2d2, v2d3, v4d1, v4d2, and v4d3. A yellow color at the gene name column annotates findings that overlap as significant proxy genes between NMR-single traits and classical lipids; purple background annotates significant findings after FF and most of the time also after PPL; tan background color annotates mainly baseline discoveries; red color letters annotate mainly NMR-single traits and classical lipids gene discoveries that concord between the two groups in time