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. Author manuscript; available in PMC: 2013 Mar 19.
Published in final edited form as: Int J Neuropsychopharmacol. 2010 Dec 21;14(9):1179–1194. doi: 10.1017/S1461145710001409

Figure 1.

Figure 1

(a) Effect of CRF on acoustic startle responding to 120 dB pulses in C57BL/6J mice. Mice received ICV injections of 0, 0.06, 0.2, or 0.6 nmol oCRF diluted in aCSF vehicle. Acoustic startle responding was measured hourly from 0 to 6 h post-administration. *p<0.05, 0.2 and 0.6 nmol, compared to vehicle group; #p < 0.05, 0.6 nmol compared to 0.06 nmol group, +p < 0.05, 0.6 nmol compared to vehicle, post-hoc test). (b) Effect of oCRF on % PPI (averaged across 69, 73, 77 dB prepulse trials) at 0–6 hours post administration. oCRF significantly decreased % PPI (*p<0.05, main effect of oCRF).