Table 3.
Effect of CRF1 antagonist (antalarmin) on atipamezole-induced changes in startle magnitude and % PPI (Mean ± SEM)
| Startle Intensity (dB) | 80
|
90
|
100
|
110
|
120
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Vehicle | Atipam. | Vehicle | Atipam. | Vehicle | Atipam. | Vehicle | Atipam. | Vehicle | Atipam. | |
|
|
|
|||||||||
| Vehicle | 18 ± 3 | 26 ± 6 | 31 ± 7 | 28 ± 8 | 59 ± 11 | 80 ± 13 | 97 ± 16 | 153 ± 22 | 95 ± 13 | 184 ± 17* |
| Antalarmin | 14 ± 1=2 | 19 ± 4 | 30 ± 5 | 43 ± 11 | 84 ± 11 | 82 ± 11 | 117 ± 18 | 144 ± 13 | 126 ± 23 | 141 ± 17 |
| Prepulse Intensity (dB) | 68
|
71
|
77
|
|||
|---|---|---|---|---|---|---|
| Vehicle | Atipam. | Vehicle | Atipam. | Vehicle | Atipam. | |
|
|
||||||
| Vehicle | 21 ± 8 | 34 ± 9 | 53 ± 5 | 57 ± 7 | 70 ± 4 | 79 ± 4 |
| Antalarmin | 27 ± 7 | 34 ± 8 | 56 ± 5 | 59 ± 7 | 70 ± 4 | 75 ± 4 |
*
p < 0.05, vs. Veh/Veh at 120 dB