Table 1.

Selection of Enzymes for which FRET-based Probes have been Reported

Enzyme Class	Specific Enzyme
Aspartate proteases	Renin [9–12], Pepsin [9,13,14], Gastricsin [13,14], Cathepsin D [9,13,15,16], Cathepsin E [16], Plasmepsins [17,18], β-Secretase [19]
Serine proteases	Cathepsin G [20–22], Trypsin [23,24], Kallikreins [24–28], Human Cytomegalovirus viral protease [29,30], Hepatitis C viral protease [31], Subtilisins [32,33], Furin [34–36], Proprotein convertase 4 [37], Subtilisin kexin isozyme 1 [38], Elastases [39–41], Signal peptidases [42,43], Dengue virus type II protease [44], Proteinase 3 [45]
Metalloproteases	Matrix metalloproteinases [46–49], Tumor necrosis factor-α convertase [50], Thermolysin [51], Dispase [51], Bacillus anthracis lethal factor protease [52], Lysostaphin [53], N-Arginine dibasic convertase [54], Enkephalinase [55], Angiotensin-converting enzyme I [10,56], Aminopeptidase P [57,58], Staphylolysin [39], Neurolysin [59], Pz peptidase [59–61], Neprilysin [59]
Cysteine proteases	Papain [24,62–64], Calpain [65], SARS main protease [66,67], Foot-and-mouth viral protease [68], Cathepsin B [24], Cathepsin L [24], Cruzipain [69]
Glucoaminidase [70]
Glycosidase	α-Amylase [71,72], Ceramide glycanase [73], Chitinases [74], Chitobiosidases [74], Cellulases [75]
Transferases	Glycosyltransferase [76]
Phosphodiesterase [77–79] Phospholipase [80–82]
Lipase/Esterase [83–86]
Nuclease [87–91]
Integrase [92]
DNA Polymerase [93,94]