Table 10.
QPCR-validated androgen-regulated genes.
| Tissue | Gene | QPCR fold change | Other similarly regulated tissues |
|---|---|---|---|
| Prostate | Odc1 | ↓4.5 fold with castration, ↑3.3 fold with DHT | Muscle, skin |
| Sqle | ↓6.3 fold with castration, ↑4.1 fold with DHT | Mammary | |
| Gadd45g | ↓3.0 fold with castration, ↑4.2 fold with DHT | ||
| Fkbp5 | ↓12.2 fold with castration, ↑13.4 fold with DHT | Muscle | |
| Nkx3.1 | ↓3.6 fold with castration, ↑4.5 fold with DHT | ||
| Zfp36l | ↑5.8 fold with castration, ↓2.8 fold with DHT | ||
| Sox4 | ↓5.7 fold with castration, ↑4.8 fold with DHT | Muscle, kidney, tibia | |
| Myom1 | ↓6.5 fold with castration | Kidney | |
| Pvalb | ↓3.2 fold with castration | Muscle, kidney | |
| Ptgis | ↓2.2 fold with castration | Muscle, skin | |
| Eno3 | ↓3.5 fold with castration | Fat, uterus | |
| Cox6a2 | ↓4.2 fold with castration | Fat | |
| Acta1 | ↓10.7 fold with castration | Muscle, uterus, tibia, skin, mammary | |
| Pou2af1 | ↓2.4 fold with castration | Tibia, ovary, mammary | |
| Col1a1 | ↓2.7 fold with castration | Muscle, tibia | |
| Fut4 | ↓21.8 fold with castration | Forebrain | |
| Cldn3 | ↑2.4 fold with castration, ↓3.5 fold with DHT | Forebrain, uterus | |
| Aytl2 | ↑1.9 fold with castration | Kidney | |
| P21 | ↑2.1 fold with DHT | Muscle, fat, forebrain | |
| Forebrain | Lrrc4c | ↓2.5 fold with castration | |
| Cldn3 | ↑3.5 fold with castration, ↓3.4 fold with DHT | Prostate, uterus | |
| P21 | ↑2.2 fold with castration | Prostate, muscle, fat | |
| Fut4 | ↑1.7 fold with castration, ↓2.2 fold with DHT | Prostate | |
| Igf1 | ↓3.0 fold with castration | Muscle, fat | |
| Ovary | Pou2af1 | ↓2.3 fold with DHT | Prostate, tibia, mammary |
| Skin | Acta1 | ↓2.9 fold with castration | Prostate, muscle, uterus, tibia, mammary |
| Ccnb1 | ↓1.8 fold with castration, ↑2.5 fold with DHT | Fat | |
| Pdk4 | ↓2.5 fold with castration, ↑1.8 fold with DHT | ||
| Myf6 | ↓2.4 fold with castration, ↑2.0 fold with DHT | Fat | |
| Odc1 | ↑2.1 fold with castration, ↓3.0 fold with DHT | Prostate, muscle | |
| Wnt5a | ↑1.9 fold with DHT | ||
| Ptgis | ↓1.5 fold with castration, ↑2.9 fold with DHT | Prostate, muscle | |
| Muscle* | Acta1 | ↓3.7 fold with castration | Prostate, uterus, tibia, skin, mammary |
| Fkbp5 | ↑3.2 fold with DHT | Prostate | |
| Pvalb | ↓4.9 fold with castration | Prostate, kidney | |
| Myot | ↑2.8 fold with DHT | ||
| Axin1 | ↑5.6 fold with DHT | ||
| Igf1 | ↓4.2 fold with castration, ↑7.0 fold with DHT | Fat, forebrain | |
| Odc1 | ↓2.7 fold with castration, ↑6.2 fold with DHT | Prostate, skin | |
| Sox4 | ↑2.2 fold with DHT | Prostate, kidney, tibia | |
| Ptgis | ↓2.1 fold with castration | Prostate, skin | |
| Ldhc | ↓2.2 fold with castration | Fat | |
| Mt1a | ↑4.1 fold with DHT | Fat, mammary | |
| Col1a1 | ↓3.2 fold with castration | Prostate, tibia | |
| P21 | ↑3.5 fold with DHT | Prostate, fat, forebrain | |
| Uterus | Zfp36l | ↑2.7 fold with DHT | Fat |
| Eno3 | ↓3.0 fold with DHT | Prostate, fat | |
| Fkbp5 | ↓2.5 fold with DHT | ||
| Acta1 | ↑4.7 fold with DHT | Prostate, muscle, tibia, skin, mammary | |
| Cldn3 | ↑2.2 fold with DHT | Prostate, brain | |
| Mmp11 | ↑3.5 fold with DHT | ||
| Col5a2 | ↓2.4 fold with DHT | ||
| Tibia bone** | Pou2af1 | ↓2.3 fold with castration, ↑2.0 fold with DHT | Prostate, ovary, mammary |
| Col1a1 | ↓2.3 fold with castration | Prostate, muscle | |
| Acta1 | ↓1.9 fold with castration, ↑1.8 fold with DHT | Prostate, muscle, uterus, skin, mammary | |
| Wap | ↑2.7 fold with castration, ↓2.5 fold with DHT | Kidney | |
| Sox4 | ↑3.5 fold with DHT | Prostate, muscle, kidney | |
| Fat** | Eno3 | ↓6.8 fold with castration, ↑2.6 fold with DHT | Prostate, uterus |
| Cox6a2 | ↓4.0 fold with castration | Prostate | |
| Ldhc | ↓1.7 fold with castration, ↑2.1 fold with DHT | Muscle | |
| P21 | ↓2.2 fold with castration, ↑2.2 fold with DHT | Prostate, muscle, forebrain | |
| Mt1a | ↑4.6 fold with DHT | Muscle, mammary | |
| Igf1 | ↓2.6 fold with castration | Muscle, forebrain | |
| Myf6 | ↑2.9 fold with DHT | Skin | |
| Zfp36l | ↓2.0 fold with castration, ↑1.7 fold with DHT | Uterus | |
| Ccnb1 | ↓2.0 fold with castration, ↑2.2 fold with DHT | Skin | |
| Kidney*** | Mmp14 | ↓2.4 fold with castration | |
| Pvalb | ↑9.4 fold with DHT | Prostate, muscle | |
| Aytl2 | ↑2.4 fold with DHT | Prostate | |
| Sox4 | ↑3.3 fold with DHT | Prostate, muscle, tibia | |
| Myom1 | ↑17.0 fold with DHT | Prostate | |
| Wap | ↓7.6 fold with castration, ↑33.9 fold with DHT | Tibia | |
| Mammary*** | Sqle | ↑7.5 fold with DHT | Prostate |
| Acta1 | ↑9.7 fold with DHT | Prostate, muscle, uterus, tibia, skin | |
| Mt1a | ↓4.3 fold with DHT | Muscle, fat | |
| Pou2af1 | ↓8.5 fold with DHT | Prostate, tibia, ovary |