Table 3.
Outcomes* at 12 months in patients with acute lung injury according to randomisation to initial trophic or full enteral feeding * Figures are means (SD) unless stated otherwise
| Trophic feeding (n=259) | Full feeding (n=228) | Treatment effect (95% CI)† | P value† | |
|---|---|---|---|---|
| Quality of life—SF-36 (population norm) | ||||
| Physical function (82, SD 9)‡ | 55 (33) | 55 (31) | 2 (−4 to 7) | 0.54 |
| Physical health summary (50, SD 10) | 39 (14) | 40 (13) | 0 (−2 to 3) | 0.76 |
| Mental health (76, SD 3) ‡ | 67 (25) | 63 (26) | 6 (1 to 10) | 0.02 |
| Mental health summary (50, SD 10) | 46 (15) | 43 (15) | 4 (1 to 6) | 0.01 |
| Quality of life—EQ-5D | ||||
| Utility score | 0.70 (0.25) | 0.71 (0.23) | 0.00 (−0.04 to 0.05) | 0.75 |
| Visual analogue scale | 71 (22) | 68 (23) | 3 (−1 to 7) | 0.14 |
| Functional activities—functional performance inventory: | ||||
| Overall score | 2.0 (0.7) | 2.1 (0.7) | −0.1 (−0.2 to 0.1) | 0.28 |
| Physical exercise subscale | 1.6 (0.9) | 1.7 (0.9) | −0.1 (−0.2 to 0.1) | 0.48 |
| Maintaining house subscale | 1.9 (0.9) | 2.0 (0.9) | 0.0 (−0.2 to 0.1) | 0.54 |
| Body care subscale | 2.5 (0.7) | 2.6 (0.6) | −0.1 (−0.2 to 0.0) | 0.12 |
| Fatigue—FACIT: | ||||
| Interval score | 63 (19) | 61 (17) | 2 (−1 to 6) | 0.16 |
| No (%) with score ≤68 | 154 (66) | 150 (68) | 0.85 (0.58 to 1.24) | 0.39 |
| Psychological symptoms§: | ||||
| Anxiety score | 7 (5) | 7 (5) | 0 (−1 to 0) | 0.31 |
| No (%) score ≥8 | 93 (39) | 102 (46) | 0.71 (0.49 to 1.02) | 0.07 |
| Depression score | 6 (5) | 6 (5) | 0 (−1 to 0) | 0.28 |
| No (%) with score ≥8 | 85 (36) | 85 (39) | 0.86 (0.59 to 1.25) | 0.44 |
| Post-traumatic stress disorder score | 0.9 (0.9) | 1.1 (1.0) | −0.1 (−0.3 to 0.1) | 0.20 |
| No (%) with score ≥1.6 | 53 (22) | 54 (25) | 0.86 (0.57 to 1.32) | 0.50 |
| Cognition—mini-mental state exam: | ||||
| Score | 25 (2) | 26 (2) | 0 (0 to 0) | 0.45 |
| No (%) with score ≤24 | 52 (22) | 44 (21) | 1.08 (0.69 to 1.69) | 0.75 |
| No (%) employed | 69 (27) | 68 (30) | 0.86 (0.58 to 1.28) | 0.46 |
FACIT= functional assessment of chronic illness therapy; FPI=functional performance inventory.
*Unknown or missing data: SF-36=physical function 11 (full), 20 (trophic); SF-36=physical health summary=12, 21; SF-36 mental health=11, 21; SF-36 mental health summary=12, 21; EQ-5D utility score=8, 21; EQ-5D visual analogue scale=9, 21; FPI overall score=3, 12; FPI physical exercise subscale=3, 12; FPI maintaining house subscale=3, 11; FPI body care subscale=3, 11; FACIT score=8, 24; anxiety score=8, 20; depression score=8, 21; post-traumatic stress disorder score=9, 22; mini-mental state exam score=17, 20; employment status=2, 5.
†Calculated from linear or logistic regression models based on generalising estimating equations with exchangeable correlation structure44 and indicator for treatment (trophic v full feeding group), time (12 v 6 month follow-up), and interaction of treatment group and time. Treatment effect represents mean difference in score for continuous measures and odds ratio for binary measures.
‡Adjusted for age and sex within linear regression model described above.
§Depression and anxiety symptoms measured with hospital anxiety and depression Scale and symptoms of post-traumatic stress disorder measured with impact of events scale-revised.