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. 2013 Mar 19;8(3):e59369. doi: 10.1371/journal.pone.0059369

Figure 5. BCL11B mediates transcriptional repression via the NuRD complex.

Figure 5

A. shRNA knock-down of CHD4 in A673 cells results in the up-regulation of BCL11B repressed genes as measured by qRT-PCR. B. A673 cells treated with the indicated dose of vorinostat for 48 hours results in the dose-dependent increase of the indicated BCL11B repressed genes as measured by qRT-PCR. C. qRT-PCR of A673 cells treated with the indicated dose of the LSD1 inhibitor, HCI-2509, for 48 hours. Error bars represent SD of three technical replicates. P-values were determined using a Student’s T-test comparing all conditions to control (Luc shRNA (A) or DMSO (B,C)) (* for p≤0.05, ** for p≤0.01, *** for p≤0.001).