Table 3. Characteristics of 672 episodes of candidemia by age strata.
| NeonatesN = 89 | InfantsN = 70 | Older childrenN = 138 | AdultsN = 223 | ElderlyN = 152 | OverallN = 672 | |
| Gender, male : female | 41∶48 | 54∶16 | 82∶56 | 132∶91 | 87∶65 | 396∶276 |
| Age*, median (range) | 16 (1–28) | 4 (1–11) | 5 (1–18) | 45 (19–60) | 76 (61–98) | 26 (0–98) |
| APACHE II score**, median (range) | 15 (6–24) | 13.5 (8–24) | 18 (4–21) | 16 (2–38) | 21.5 (10–39) | 18 (2–39) |
| Duration (days) of hospitalization before candidemia, median (range) | 12 (0–28) | 19 (0–146) | 13 (0–176) | 17 (0–162) | 20 (0–130) | 15 (0–176) |
| Admission to an ICU | 70 (78.7) | 34 (48.6) | 36 (26.1) | 83 (36.8) | 78 (51.3) | 300 (44.6) |
| Cancer | – | 4 (5.7) | 46 (33.3) | 60 (26.9) | 41 (27.0) | 151 (22.5) |
| Hematological malignancy | – | 1 (1.4) | 31 (22.5) | 29 (13.0) | 8 (5.3) | 69 (10.3) |
| Solid tumor | – | 3 (4.3) | 15 (10.9) | 31 (13.9) | 33 (21.7) | 82 (12.2) |
| Cardiac disease | 18 (20.2) | 15 (21.4) | 14 (10.1) | 34 (15.2) | 76 (50.0) | 157 (23.4) |
| Neurological disease | 6 (6.7) | 11 (5.7) | 27 (19.6) | 31 (13.9) | 43 (28.3) | 118 (17.6) |
| Lung disease | 27 (30.3) | 19 (27.1) | 15 (10.9) | 46 (20.6) | 60 (39.5) | 167 (24.9) |
| Diabetes mellitus | 1 (1.1) | – | 4 (2.9) | 33 (14.8) | 38 (25.0) | 76 (11.3) |
| Renal failure | 10 (11.2) | 10 (14.3) | 19 (13.8) | 55 (24.7) | 56 (36.8) | 150 (22.3) |
| Chronic renal failure | – | 1 (1.4) | 9 (6.5) | 24 (10.8) | 24 (15.8) | 58 (8.6) |
| Liver disease | 2 (2.2) | 6 (8.6) | 8 (5.8) | 34 (15.2) | 18 (11.8) | 68 (10.1) |
| Surgery | 26 (29.2) | 27 (38.6) | 58 (42.0) | 105 (47.1) | 78 (51.3) | 294 (43.8) |
| Abdominal surgery | 18 (20.2) | 17 (24.3) | 29 (21.0) | 54 (24.2) | 38 (25.0) | 156 (23.2) |
| Mechanical ventilation | 60 (67.4) | 31 (44.3) | 32 (23.2) | 102 (45.7) | 82 (53.9) | 307 (45.7) |
| Parenteral nutrition | 43 (48.3) | 18 (25.7) | 26 (18.8) | 64 (28.7) | 41 (27.0) | 192 (28.6) |
| Dialysis | 3 (3.4) | 3 (4.3) | 8 (5.8) | 35 (15.7) | 27 (17.8) | 76 (11.3) |
| Neutropenia | 1 (1.1) | 4 (5.7) | 30 (21.7) | 19 (8.5) | 3 (2.0) | 57 (8.5) |
| Central venous catheter | 63 (70.8) | 38 (54.3) | 91 (65.9) | 167 (74.9) | 124 (81.6) | 483 (71.9) |
| Receipt of antibiotic | 85 (95.5) | 68 (97.1) | 131 (94.9) | 211 (94.6) | 140 (92.1) | 635 (94.5) |
| Receipt of corticosteroids | 12 (13.5) | 16 (22.9) | 48 (34.8) | 87 (39.0) | 62 (40.8) | 225 (33.5) |
| Previous use of fluconazole | 15 (16.9) | 3 (4.3) | 22 (15.9) | 48 (21.5) | 19 (12.5) | 107 (15.9) |
NOTE: Numbers are no. (%) of patients, unless otherwise indicated. APACHE = Acute Physiologic and Chronic Health Evaluation;
Infants defined as children older than 28 days and younger than 1 year; Elderly defined as patients older than 60 years.
*
days for neonates, months for infants and years for the other age strata and overall.
**
data available for 258 episodes.