Table 5. In vitro susceptibility of Candida species to four antifungal agents.
| Species (N) | Antifungal agent | MIC* (µg/ml) | SDD or I, n (%) | Resistant, n (%) | ||
| Range | MIC 50 | MIC 90 | ||||
| C. albicans (253) | Amphotericin B | 0.125–1.0 | 0.5 | 1.0 | NA | 0 |
| Fluconazole | 0.125–4.0 | 0.125 | 0.5 | 1 (0.4) | 0 | |
| Voriconazole | 0.03–0.125 | 0.03 | 0.03 | 0 | 0 | |
| Anidulafungin | 0.03–0.5 | 0.03 | 0.125 | 1 (0.4) | 0 | |
| C. parapsilosis (178) | Amphotericin B | 0.25–1.0 | 0.5 | 1.0 | NA | 0 |
| Fluconazole | 0.125–4.0 | 0.25 | 1.0 | 2 (1.1) | 0 | |
| Voriconazole | 0.03–0.25 | 0.03 | 0.25 | 0 | 0 | |
| Anidulafungin | 0.03–2.0 | 1.0 | 2.0 | 0 | 0 | |
| C. tropicalis (118) | Amphotericin B | 0.25–1.0 | 0.5 | 1.0 | NA | 0 |
| Fluconazole | 0.125–1.0 | 0.25 | 0.5 | 0 | 0 | |
| Voriconazole | 0.03–0.125 | 0.03 | 0.03 | 0 | 0 | |
| Anidulafungin | 0.03–0.5 | 0.03 | 0.25 | 2 (1.7) | 0 | |
| C. guilliermondii (44) | Amphotericin B | 0.25–1,0 | 0.5 | 1.0 | NA | 0 |
| Fluconazole | 0.125–16 | 2.0 | 8.0 | ND | ND | |
| Voriconazole | 0.03–0.5 | 0.06 | 0.25 | 0 | 0 | |
| Anidulafungin | 0.03–2.0 | 1.0 | 2.0 | ND | ND | |
| C. glabrata (42) | Amphotericin B | 0.25–1.0 | 0.5 | 1.0 | NA | 0 |
| Fluconazole | 0.25–64 | 4.0 | 16 | 39 (92.9) | 3 (7.1) | |
| Voriconazole | 0.03–2.0 | 0.125 | 0.5 | 0 | 0 | |
| Anidulafungin | 0.03–0.25 | 0.06 | 0.125 | 2 (4.8) | 0 | |
| C. krusei (18) | Amphotericin B | 0.5–1.0 | 0.5 | 1.0 | NA | 0 |
| Fluconazole | 8.0–32 | 16 | 32 | 0 | 18 (100) | |
| Voriconazole | 0.03–0.25 | 0.125 | 0.25 | 0 | 0 | |
| Anidulafungin | 0.03–0.125 | 0.06 | 0.125 | 0 | 0 | |
MIC = minimal inhibitory concentration; SDD = susceptible, dose-dependent; I = intermediate; NA = not applicable; ND = not defined.