Table 2.
Stage Wise association statistics for the eleven SNPs which were associated in stage-2 following discovery in stage-1 analysis:
| SNP (Minor Allele Frequency) |
POSH stage-1 HR (95% CI), p-value |
POSH stage-2 replications HR (95% CI), p-value |
Stage-1 and Stage-2 meta-analysis results |
I2 derived from Cochran’s Q-statistic, p- value for Q-statistic |
|---|---|---|---|---|
| rs421379 (0.05) | 1.98 (1.46-2.70), p=1.2×10−5 | 1.42 (1.11-1.8), p=0.005 | 1.61 (1.33-1.96), p=9.5 × 10−7 | 63.7%, p=0.10 |
| rs3884558 (0.07) | 1.84 (1.40-2.41), p=1.3×10−5 | 1.29 (1.05-1.57), p=0.01 | 1.46 (1.24-1.72), p=3.9 × 10−6 | 76.4%, p=0.04 |
| rs971398 (0.17) | 1.52 (1.23-1.88, p=1.2 × 10−4) | 1.24 (1.05-1.47, p=0.01) | 1.34 (1.18-1.53, p=1.2 × 10−5 | 46.3%, p=0.17 |
| rs7910841 (0.28) | 0.64 (0.51-0.80, p=8.2 × 10−5) | 0.83 (0.72-0.96, p=0.01) | 0.77 (0.68-0.87), p=2.3 × 10−5 | 72.5%, p=0.06 |
| rs12523819 (0.28) | 0.64 (0.51-0.80, p=1.1 × 10−4) | 0.86 (0.74-0.99), p=0.04 | 0.77 (0.88-0.87), p=2.3 × 10−5 | 78.6%, p=0.03 |
| rs3785982 (0.12) | 1.75 (1.36-2.24, p=1.3 × 10−5) | 1.24 (1.03-1.48, p=0.02) | 1.40 (1.21-1.62), p=7.9 × 10−6 | 79.1%, p=0.03 |
| rs2774307 (0.26) | 1.51 (1.24-1.85, p=4.3 × 10−5) | 1.21 (1.05-1.40, p=0.01) | 1.30 (1.16-1.47), p=7.9 × 10−6 | 67.8%, p=0.08 |
| rs10220397 (0.23) | 0.63 (0.50-0.79, p=8.6 × 10−5) | 0.85 (0.73-0.99, p=0.04) | 0.77 (0.68-0.88), p=8.3 × 10−5 | 78.1%, p=0.03 |
| rs303850 (0.42) | 1.48 (1.22-1.79, p=5.2 × 10−5) | 1.13 (1.00-1.29, p=0.05) | 1.23 (1.10-1.36), p=1.5 × 10−4 | 81.1%, p=0.02 |
| rs1387389 (0.36) | 1.47 (1.22-1.77, p=5.0 × 10−5) | 1.20 (1.05-1.37, p=0.007) | 1.28 (1.16-1.43), p=3.8 × 10−6 | 66.6%, p=0.08 |
| rs1513848 (0.07) | 1.87 (1.41-2.46, p=1.0 × 10−5) | 1.25 (1.01-1.55, p=0.04 | 1.45 (1.22-1.72), p=1.6 × 10−5 | 80.2%, p=0.02 |