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. 2013 Mar 7;8:4. doi: 10.1186/1749-8104-8-4

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Copyright ©2013 Molina-Hernández et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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HA activates H₁R to increase the number of clones with differentiated neurons. (A) Significant increase in the number of colonies with microtubule associated protein 2 (MAP2)+ neurons promoted by HA and its prevention by chlorpheniramine (Chlorph.) **P <0.01 and ***P <0.001 versus Control. (B-D) Representative micrographs of clonal colonies after immunocytochemical detection of mature neurons (MAP2+; red), astrocytes (GFAP+; green) and nuclei (blue) in Control (B), HA-treated (C) and HA + chlorpheniramine (Chlorph.)-treated (D) cells are shown. Scale bar = 100 μm. GFAP, glial fibrillary acidic protein; HA, histamine; H₁R, histamine receptor type 1.