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. 2013 Mar 12;11:42. doi: 10.1186/1477-7525-11-42

Table 1.

Summary of MOS-HIV effect sizes overall and in treatment naïve and treatment-experienced HIV-infected patients

Study Treatment Physical health summary
Mental health summary
Mean change % change Effect size Mean change % change Effect size
Bucciardini et al. 2007 [13]
ddI/d4T/EFV
4.7
9.4%
−0.43
4.0
8.2%
−0.40
ddI/d4T/NFV
0.7
1.5%
−0.05
2.8
5.8%
−0.28
ddI/d4T/EFV/NFV
2.0
4.2%
−0.17
0.0
0.0%
0.00
Stangl et al. 2007a[23]
HAART + weekly home visits
15.0*
38.3%
−1.53
14.2*
35.5%
−1.27
Average for treatment-naïve patients [weighted]
2.5
0.1
−0.55
2.3
0.1
−0.49
Nuesch et al. 2009b[17]
Continuous treatment
−1.3
−2.4%
0.20
0.8
1.5%
0.03
Scheduled treatment interruptionsc
−1.2
−2.2%
0.19
0.4
0.8%
−0.15
Huang et al. 2008 [14]
TPV/r (tipranavir / ritonavir)
0.2
0.4%
−0.02
1.4
2.9%
−0.13
CPI/r (boosted comparitor PI)
−0.3
−0.6%
0.03
1.7
3.6%
−0.17
Powers et al. 2006 [18]
Intermittent groupd
0.6
1.1%
−0.07
3.2*
5.9%
−0.37
Continuous groupe
1.0
1.9%
−0.09
3.2
5.9%
0.00
Average for treatment-experienced patients [weighted]
−0.2
0.0
0.04
1.5
0.0
−0.13
Overall mean [weighted] 0.7 0.1 −0.19 1.8 0.1 −0.27

Mean change calculated as final score – baseline score. % change calculated as [(final score - baseline score) / baseline score] × 100. Effect size calculated as (final score – baseline score) / standard deviation of baseline score.

*P<0.05; Note: significance of mean change scores not available for all studies; aProspective non-randomized controlled trial; bPatient population includes treatment-naïve and treatment-experienced patients (analyzed together); cCD4-guided treatment with threshold of 350 cells/μL for interruption/re-initiation of ARV therapy; d7 cycles of 4 weeks off/8 weeks on HAART; eContinue HAART regimen for 22 weeks.