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Methadone significantly increased intracellular accumulation of calcein in a dose dependent manner in wild-type P-gp, as well as the two variant-types of P-gp. Verapamil 10 µM was used as a positive control.Data were presented as mean ± SE of at least three experiments, each in triplicate. *p<0.05 compared withcalcein-AM uptake without methadone.
