Table 2. The most enriched GO categories of modular enrichment in each gene clusters uncovered by LRR from yeast dataset.
Cluster | No. of genes with in functional category | Major GO categories | Corrected P-value |
C1(121genes) | 10 | Starch and sucrose metabolism | 2.99342E-11 |
C2(86genes) | 4 | structural constituent of cytoskeleton | 4.7389E-2 |
C3(30genes) | 14 | response to stress | 6.33965E-30 |
C4(663genes) | 151 | integral to membrane | 3.67556E-2 |
C5(45genes) | 27 | oxidation-reduction process | 1.04843E-25 |
C6(38genes) | 3 | DNA repair | 4.92582E-5 |
C7(69genes) | 10 | ion transport | 6.84207E-13 |
C8(71genes) | 16 | Glycolysis/Gluconeogenesis | 3.15299E-19 |
C9(181genes) | 92 | ribosome biogenesis | 9.62533E-119 |
C10(87genes) | 5 | prospore membrane | 2.30387E-5 |
C11(34genes) | 10 | helicase activity | 9.29836E-11 |
C12(414genes) | 10 | hydrolase activity | 2.44361E-5 |
C13(551genes) | 11 | regulation of transcription, DNA-dependent | 2.0876E-3 |
C14(114genes) | 37 | cellular amino acid biosynthetic process | 2.33136E-41 |
C15(393genes) | 3 | mitotic recombination | 1.67731E-4 |
C16(25genes) | 20 | transposition, RNA-mediated | 3.23626E-35 |
C17(130genes) | 116 | structural constituent of ribosome | 3.58803E-202 |
C18(454genes) | 77 | Biosynthesis of secondary metabolites | 1.57577E-32 |
C19(83genes) | 3 | sporulation resulting in formation of a cellular spore | 2.12806E-2 |
C20(511genes) | 3 | oxidation-reduction process | 4.34938E-4 |
C21(75genes) | 3 | transferase activity, transferring phosphorus-containing groups | 9.06387E-3 |
C22(27genes) | 3 | metal ion binding | 1.04585E-5 |
C23(675genes) | 5 | transport | 5.76795E-3 |
C24(183genes) | 92 | ribisome biogenesis | 3.82873E-112 |
C25(553genes) | 73 | transcription, DNA-dependent | 2.91171E-7 |
C26(287genes) | 35 | extracellular region | 2.62718E-24 |
C27(50genes) | 31 | mitochondrion | 2.79651E-53 |
C28(801genes) | 38 | vesicle-mediated transport | 1.40759E-8 |
C29(347genes) | 5 | guanyl-nucleotide exchage factor activity | 1.6044E-4 |
C30(258genes) | 30 | fungal-type cell wall | 1.30198E-22 |
The columns of the table summarize the total sizes of the module (numbers in parentheses), the number of genes annotated in the cluster, the GO categories associated with the cluster, and the P-value after FDR correction.