Table 3.

Single nucleotide polymorphisms with association with asthma

Gene	rs-number	Alleles	Number of associations	Minor allel related to	Association ref.	No association ref.
CD14	rs2569190	C > T	1 out of 15 (duplication [20,21])	decreased asthma severity	[19]	[10,12,13,20,21,34,36-40,42-45]
CD14	rs4914	G > C	1 out of 2 (duplication [20,21])	decreased asthma incidence	[20,21]	[38]
TLR1	rs5743595	T > C	1 out of 1	atopic asthma	[27]	NA
TLR1	rs4833095	A > G	1 out of 1	atopic asthma	[27]	NA
TLR2	rs4696480	A > T	3 out of 5 (partial duplication [26,56])	asthma/current asthma symptoms	[25,26,56]	[27,45]
TLR2	rs3804099	T > C	1 out of 6 (partial duplication [26,56])	nonatopic asthma (inverse)	[27]	[25,26,38,45,56]
TLR2	rs3804100	T > C	1 out of 6 (partial duplication [26,56])	allergic asthma (inverse)	[38]	[21,25,26,45,56]
TLR2	rs1898830	A > G	1 out of 4	asthma	[26]	[21,27,56]
TLR2	rs5743708	G > A	1 out of 2	asthma severity in atopic children	[59]	[43]
TLR4	rs2737190	A > G	1 out of 1	(non-atopic) asthma	[27]	NA
TLR4	rs4986790	A > G	3 out of 10	asthma, atopic asthma and asthma severity in atopic children	[34,39,59]	[41,43-45,55,56,60]
TLR4	rs4986791	C > T	1 out of 4	mild atopic asthma	[34]	[27,56,60]
TLR6	rs6531666	T > C	1 out of 1	asthma	[45]	NA
TLR6	rs5743789	T > A	1 out of 1	atopic asthma	[27]	NA
TLR6	rs5743798	C > T	1 out of 1	asthma	[45]	NA
TLR6	rs5743810	C > T	2 out of 5	(atopic) asthma	[27,61]	[21,45,57]
TLR7	rs179008	A > T	1 out of 2	asthma	[28]	[27]
TLR8	rs2407992	G > C	1 out of 1	asthma	[28]	NA
TLR9	rs187084	T > C	1 out of 3	asthma	[27]	[21,45]
TLR10	rs4129009	A > G	1 out of 2	atopic asthma inverse	[27]	[45]
TLR10	rs11096957	A > C	1 out of 3	asthma	[21]	[45,57]

Ref: reference, TLR: Toll-Like Receptor, NA: not applicable.