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Treated defects 21 days post-treatment contain less GAG, col II and col I than controls. Percent of the soft repair tissue present in each drill hole cross-section in cryosections taken in the middle of the holes containing (A) collagen type I, (B) collagen type II, and (C) Safranin O-stained glycosaminoglycan, at 21 days (N=4) post-treatment. (mean ± standard deviation). **p<0.005, ***p<0.0005.
