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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Transl Res. 2013 Jan 29;161(4):205–216. doi: 10.1016/j.trsl.2013.01.002

Table 2. Clinical trials in the gene therapy of osteoarthritis.

Transgene Vector
Ex/In Vivo		 Phase PI,
Institution
or Sponsor		 OBA
Protocol
Number		 Status Number
of
subjects		 Ref.
TGF-β1 Retrovirus
Ex Vivo		 I Ha,
Kolon Life
Sciences,
Korea		 NA Closed 12 42
TGF-β1 Retrovirus
Ex Vivo		 I Mont
TissueGene
Inc		 0307-594 Closed 9
TGF-β1 Retrovirus
Ex Vivo		 IIa Ha,
Kolon Life
Sciences,
Korea		 NA Closed 28 43
TGF-β1 Retrovirus
Ex Vivo		 II Mont
TissueGene
Inc		 0912-
1016		 Open 100
IL-1Ra AAV
In Vivo		 I Evans Pre-IND

OBA : Office of Biotechnology Activities

NA = Not Applicable

Adapted from reference 73