Figure 3. Partner preference and elevated-plus maze behavior in shRNA-pvAvpr1a and scrambled injected male prairie voles.
After 24hr of mated cohabitation with a female, scrambled injected males spent significantly more time in social contact with the partner than the stranger, whereas shRNA injected males spent significantly more time with the stranger (A). The percent of animals forming a partner preference, defined as spending more than twice as much time with the partner than the stranger, differed significantly between groups, with no shRNA injected males forming a preference after 24hr (B). shRNA injected males displayed decreased measures of anxiety-like behaviors, with a higher frequency of distal, but not entire, open arm entries (C), a greater distance moved in the distal and entire open arms (D), and less time spent in the central platform (E). Asterisks indicates p-values <0.05.