Table 1. Comparison of different biosensors for MTB detection.
| Technology | Biomarker | Limit of detection | Reference |
|---|---|---|---|
| QCM | Whole MTB bacilli | 105 CFUmL | (He and Zhang, 2002) |
| MSPQC | NH3 & CO2 absorption |
10 CFU/mL | (Ren et al., 2008a) |
| RBS Breathalyzer Fluorometry |
Ag85B antigen | 50-75 CFU/mL | (McNerney et al., 2010) |
| Interferometric Biosensor | 38-kDa antigen | NR | (Nagel et al., 2008) |
| SPR | CFP-10 antigen | 100 ng/mL | (Hong et al., 2011) |
| DMR | NR | 20 CFU/mL | (Chun, 2009, Lee et al., 2008) |
| SPCE | Ag360 & Ag231 antigens |
1 ng/ml | (Diaz-Gonzalez et al., 2005) |
| Enzymatic Immonosensor |
Antibody to mycolic acid |
NR | (Thanyani et al., 2008) |
| Electroosmosis mediated Microtip |
Whole MTB bacilli | 8 × 103 CFU/mL | (Yeo et al., 2009) |
| Acoustic Sensor | Whole MTB bacilli | 2 × 103 CFU/mL | (Stocher et al., 2003) |
Abbreviations: QCM, quartz crystal microbalance; MSPQC, multi-channel series piezoelectric quartz crystal; RBS, Rapid Biosensor Systems; SPR, surface plasmon resonance; DMR, diagnostic magnetic resonance; SPCE, screen-printed carbon electrode; MTB, Mycobacterium tuberculosis; CFU, colony forming unit; NR, Not reported.