Table 1. IGFBPs increase intracellular calcium concentration via pertussis toxin-sensitive and -insensitive signaling pathways in MCF-7 and C2 proliferative cells.

IGFBP	MCF-7 cells		C2 proliferative cells
	Increase of calcium concentration	pertussis toxin	Increase of calcium concentration	pertussis toxin
IGFBP-1	−		−
IGFBP-2	+	S	−
IGFBP-3	+	S	+	NS
IGFBP-4	+	NS	−
IGFBP-5	−		+	S
IGFBP-6	+	NS	+	NS

S: sensitive, NS: non sensitive.