Table 1.
Characteristics of the study population at baseline and after 1 month of CPAP
| |
Mild/moderate OSA patients (n = 36) |
Severe OSA patients (n = 31) |
||
|---|---|---|---|---|
| Baseline | Post CPAP | Baseline | Post CPAP | |
| Age (yrs) |
48 ± 10.4 |
NA |
51 ± 6.3 |
NA |
| Body mass index (Kg/m2) |
29 ± 3.8* |
30 ± 3.8 |
35 ± 5.1* |
35 ± 5.0 |
| Epworth score |
11 ± 6.2# |
3.1 ± 2.5 |
12 ± 6.3 # |
4.2 ± 3.2 |
| RDI (n/h) |
16 ± 6.8* |
# 3 ± 2.5 |
66 ± 24.2# |
4 ± 2.3 |
| Mean SaO2 (%) |
95 ± 1.3* |
# 96 ± 1.2 |
91 ± 4.8# |
95 ± 1.2 |
| Minimum SaO2 (%) |
86 ± 4.8* |
# 93 ± 2.1 |
71 ± 9.9# |
93 ± 2.2 |
| SaO2 < 90% (% of TST) |
1 ± 3.2* |
# 0 ± 0.2 |
27 ± 26.6# |
0 ± 0.1 |
| ODI (n/h) |
10 ± 9.5* |
# 0 ± 0.2 |
52 ± 20.5# |
0 ± 0.2 |
| Arousal index (n/h) |
23 ± 8.1* |
# 16 ± 9.2 |
53 ± 18# |
14 ± 7 |
| Compliance (h/night) |
NA |
6.3 ± 1.3 |
NA |
6.6 ± 0.9 |
| 95th percentile CPAP pressure (cmH2O) |
NA |
11.5 ± 1.8 |
NA |
13.2 ± 1.5 |
| 24h MAP (mmHg) |
91 ± 6.8* |
92 ± 6.9 |
97 ± 8.1# |
92 ± 9 |
| Daytime BP (mmHg) |
|
|
|
|
| Systolic |
127 ± 8.3* |
127 ± 8.8 |
134 ± 10.9# |
130 ± 10.1 |
| Diastolic |
81 ± 6.2* |
70 ± 7.5 |
85 ± 5.8 # |
80 ± 6.2 |
| Nighttime BP (mmHg) |
|
|
|
|
| Systolic |
114 ± 7.9* |
116 ± 10.3 |
125 ± 14.2# |
119 ± 12.9 |
| Diastolic |
70 ± 7.6* |
70 ± 7.5 |
76 ± 9.3# |
73 ± 8.9 |
| Nox 11pm (μm) |
34.3 ± 21.8+ |
41.3 ± 22.2 |
34.5 ± 21.9 & |
41.4 ± 19.8 |
| Nox 4am (μm) |
29.4 ± 15.4+ |
37.7 ± 21.1 |
27.2 ± 14.4 & |
37.4 ± 17.9 |
| Nox 7am (μm) |
26.4 ± 14.1+ |
36.6 ± 19.5 |
24.3 ± 16.8 & |
35.2 ± 16.7 |
| ΔNOX (%) |
16.5 ± 18.5+ |
9.3 ± 16.3 |
27.6 ± 20.1 & |
0.79 ± 52.2 |
| U-NE (μg/24h) | 48.5 ± 19.9* | 47 ± 21.3 | 73.9 ± 30.1# | 55.4 ± 21.8 |
Values shown as mean ± SD. RDI, respiratory disturbance index; SaO2, arterial oxygen saturation; TST, total sleep time; ODI, oxygen desaturation index; MAP, mean arterial pressure; BP, blood pressure; NOX, nitrate levels; ΔNOX, percentage decrease in NOx during the night; U-NE, urinary norepinephrine; NA, Not applicable.
*: p < 0.05 comparison of baseline values between patients with severe and mild-moderate OSA (unpaired t-test).
#: p < 0.05 comparison between pre- and post-CPAP values (paired t-test).
+ p < 0.05 comparison between different time points and between pre- and post-CPAP for patients with mild-moderate OSA (multivariate ANOVA analysis).
& p < 0.05 comparison between different time points and between pre- and post-CPAP for patients with severe OSA (multivariate ANOVA analysis).