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Proposed changes in the active site of Ct-FDH with the oxidized or reduced coenzyme bound at different stages of catalysis. A and B, bound NADP+ without and with formation of the covalent bond between Cys707 and the nicotinamide ring, respectively. C and D, NADPH bound in the extended (modeled from the C707A enzyme structure, PDB 3RHR [23]) or contracted (modeled from wt Ct-FDH/thio-NADP+ complex) conformation, correspondingly.
