Table 1.
Overview of Research Projects Being Conducted by the Transdisciplinary Research in Energetics and Cancer (TREC) Centers, 2011-2016.
| TREC Center | Project Title (Leader) | Age | Sex | N | Study Design | Anthropometrics | Physical Activity | GIS | Diet | Blood Biomarkers | Genetics |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Harvard | Sleep Duration, Energy Balance, and Insulin Resistance in Children (Taveras) | 0-12 | M/F | ~1300 | Cohort | x | x | x | x | x | x |
| Environmental and Lifestyle Factors, Obesity and Cancer-related Biomarkers (Hu) | 45-80 | M/F | 8750 | Cohort | x | x | x | x | x | x | |
| Energetics, Fatal Prostate Cancer, and Overall Survivorship (Ma) | 40-84 | M | 22,071 | Cohort | x | x | x | x | x | x | |
| Impact of Exercise and Metformin on Hyperinsulinemia in Colorectal Cancer Survivors (Meyerhardt) | ≥ 21 | M/F | 200 | RCT | x | x | x | x | |||
| UCSD | Role of Inflammation and Insulin Resistance in Mouse Models of Breast Cancer (Olefsky) | NA | F | NA | Animal | x | x | ||||
| Diet Composition and Genetics: Effects on Weight, Inflammation, and Biomarkers (Rock) | ≥ 21 | F | 234 | RCT | x | x | GPS | x | x | x | |
| Weight Loss, Mechanisms, and Mortality among Breast Cancer Survivors (Patterson) | >50 | F | 340 | RCT | x | x | GPS | x | |||
| Advancing Assessment of Energy Expenditure in Women with Increased Cancer Risk (Kerr) | ≥ 21 | F | NAa | NAa | x | x | GPS | x | |||
| UPenn | Impact of Exercise and Caloric Restriction on Cancer Recurrence in Mice (Chodosh) | NA | F | NA | Animal | x | x | ||||
| Women in Steady Exercise Research (WISER) Survivor Trial (Schmitz) | >50 | F | 555 | RCT | x | x | x | x | |||
| Breast Cancer-related Lymphedema: Cost of Illness and Cost Effectiveness of Alternative Management Strategies (Schwartz) | 30-70 | F | NAb | Model | x | x | x | ||||
| WUSTL | Transgenerational Animal Models of Nutritional Impact on Cancer Predisposition (Moley) | NA | M/F | NA | Animal | x | x | ||||
| Energy Balance and Post-Radical Prostatectomy Urinary and Sexual Function: PIE (Prostatectomy, Incontinence, Erectile function (Wolin) | All | M | 500 | Cohort | x | x | |||||
| SHOW-ME Study (Supports at Home and Work for Maintaining Energy Balance) (Hoehner) | 21-65 | M/F | ~2000 | Cross-sectional | x | x | x | x | |||
| Social Determinants in the Link Between Obesity and Cancer (Hovmand) | All | M/F | 5000 | Model | TBD | TBD | TBD | TBD | TBD | TBD |
Abbreviations: Harvard = Harvard University; UCSD = University of California, San Diego; UPenn = University of Pennsylvania; WUSTL = University of Washington in St. Louis; NA = Not Applicable; RCT = Randomized Clinical Trial; GIS = Geographic Information Systems; GPS = Global Positioning System; TBD = To Be Determined.
a
This study provides objective energy expenditure measurements to the 2 RCTs being conducted at UCSD.
b
This study will conduct cost-effectiveness of the RCT being conducted at Penn.