Table 3:
Characteristic | ABO blood type, mean ± SE | Factor V Leiden R506Q, mean ± SE | Prothrombin G20210A, mean ± SE | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
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|
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O n = 22 403 (39%) | Non-O n = 34 557 (61%) | p value‡ | Noncarrier n = 52 103 (91%) | Heterozygous n = 4 730 (8%) | Homozygous n = 127 (0.2%) | p value‡ | Noncarrier n = 55 770 (98%) | Heterozygous n = 1 183 (2%) | Homozygous n = 6 (0.01%)§ | p value‡ | |
Primary hemostasis | |||||||||||
| |||||||||||
Platelets, 109/L | 280 ± 0.5 | 281 ± 0.4 | 0.1 | 281 ± 0.3 | 280 ± 1.0 | 281 ± 6.3 | 0.6 | 281 ± 0.3 | 285 ± 2.1 | 275 ± 27 | 0.1 |
| |||||||||||
Mean platelet volume, fL | 7.7 ± 0.006 | 7.7 ± 0.005 | 0.3 | 7.7 ± 0.004 | 7.7 ± 0.01 | 7.6 ± 0.07 | 0.5 | 7.7 ± 0.004 | 7.7 ± 0.03 | 8.1 ± 0.5 | 0.3 |
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Coagulation | |||||||||||
| |||||||||||
INR, ratio | 0.993 ± 0.002 0.994 ± 0.001 | < 0.001 | 0.992 ± 0.001 | 1.010 ± 0.004 | 1.119 ± 0.043 | 0.1 | 0.994 ± 0.001 | 0.991 ± 0.009 | 1.008 ± 0.039 | < 0.001 | |
| |||||||||||
Coagulation factor | 103.38 ± 0.16 103.68 ± 0.13 | 0.02 | 103.63 ± 0.1 | 103.04 ± 0.4 | 94.88 ± 3.1 | 0.4 | 103.50 ± 0.1 | 106.76 ± 0.8 | 97.00 ± 14 | < 0.001 | |
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II + VII + X, % | |||||||||||
| |||||||||||
APTT, s | 29.4 ± 0.03 | 28.4 ± 0.02 | < 0.001 | 28.8 ± 0.02 | 28.8 ± 0.06 | 29.0 ± 0.32 | 0.6 | 28.8 ± 0.02 | 29.9 ± 0.1 | 30.5 ± 1.3 | < 0.001 |
| |||||||||||
Fibrinogen, μmol/L | 11 ± 0.02 | 11 ± 0.02 | 0.1 | 11 ± 0.01 | 11 ± 0.04 | 11 ± 0.35 | 0.2 | 11 ± 0.01 | 11 ± 0.08 | 10 ± 0.62 | 0.02 |
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Inflammation | |||||||||||
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CRP, mg/L | 2.7 ± 0.03 | 2.8 ± 0.03 | 0.05 | 2.7 ± 0.02 | 2.6 ± 0.06 | 3.3 ± 0.83 | 0.5 | 2.7 ± 0.02 | 2.9 ± 0.15 | 2.5 ± 1.24 | 0.01 |
| |||||||||||
Leukocytes, 109/L | 7.42 ± 0.02 | 7.38 ± 0.01 | 0.01 | 7.39 ± 0.01 | 7.43 ± 0.03 | 7.44 ± 0.16 | 0.03 | 7.39 ± 0.01 | 7.43 ± 0.06 | 6.38 ± 0.50 | 0.6 |
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Complement C3, g/L | 1.14 ± 0.001 | 1.15 ± 0.001 | < 0.001 | 1.14 ± 0.001 | 1.14 ± 0.003 | 1.16 ± 0.021 | 1.0 | 1.14 ± 0.001 | 1.15 ± 0.006 | 1.08 ± 0.080 | 0.1 |
Note: APTT = activated partial thromboplastin time, CRP = C-reactive protein, INR = international normalized ratio, SE = standard error.
Unadjusted values from study entry are presented because we were examining differences by genotypes usually unconfounded by cardiovascular risk factors.
Numbers vary slightly depending on availability of measurements.
Wilcoxen rank sum tests and tests for trend.
One homozygous participant receiving warfarin was excluded.