Skip to main content
. 2013 Mar 19;185(5):E229–E237. doi: 10.1503/cmaj.121636

Table 3:

Primary hemostasis, coagulation and inflammatory parameters* according to ABO blood type, factor V Leiden R506Q and prothrombin G20210A in the Copenhagen General Population Study

Characteristic ABO blood type, mean ± SE Factor V Leiden R506Q, mean ± SE Prothrombin G20210A, mean ± SE



O n = 22 403 (39%) Non-O n = 34 557 (61%) p value Noncarrier n = 52 103 (91%) Heterozygous n = 4 730 (8%) Homozygous n = 127 (0.2%) p value Noncarrier n = 55 770 (98%) Heterozygous n = 1 183 (2%) Homozygous n = 6 (0.01%)§ p value
Primary hemostasis

 Platelets, 109/L 280 ± 0.5 281 ± 0.4 0.1 281 ± 0.3 280 ± 1.0 281 ± 6.3 0.6 281 ± 0.3 285 ± 2.1 275 ± 27 0.1

 Mean platelet volume, fL 7.7 ± 0.006 7.7 ± 0.005 0.3 7.7 ± 0.004 7.7 ± 0.01 7.6 ± 0.07 0.5 7.7 ± 0.004 7.7 ± 0.03 8.1 ± 0.5 0.3

Coagulation

 INR, ratio 0.993 ± 0.002 0.994 ± 0.001 < 0.001 0.992 ± 0.001 1.010 ± 0.004 1.119 ± 0.043 0.1 0.994 ± 0.001 0.991 ± 0.009 1.008 ± 0.039 < 0.001

 Coagulation factor 103.38 ± 0.16 103.68 ± 0.13 0.02 103.63 ± 0.1 103.04 ± 0.4 94.88 ± 3.1 0.4 103.50 ± 0.1 106.76 ± 0.8 97.00 ± 14 < 0.001

 II + VII + X, %

 APTT, s 29.4 ± 0.03 28.4 ± 0.02 < 0.001 28.8 ± 0.02 28.8 ± 0.06 29.0 ± 0.32 0.6 28.8 ± 0.02 29.9 ± 0.1 30.5 ± 1.3 < 0.001

 Fibrinogen, μmol/L 11 ± 0.02 11 ± 0.02 0.1 11 ± 0.01 11 ± 0.04 11 ± 0.35 0.2 11 ± 0.01 11 ± 0.08 10 ± 0.62 0.02

Inflammation

 CRP, mg/L 2.7 ± 0.03 2.8 ± 0.03 0.05 2.7 ± 0.02 2.6 ± 0.06 3.3 ± 0.83 0.5 2.7 ± 0.02 2.9 ± 0.15 2.5 ± 1.24 0.01

 Leukocytes, 109/L 7.42 ± 0.02 7.38 ± 0.01 0.01 7.39 ± 0.01 7.43 ± 0.03 7.44 ± 0.16 0.03 7.39 ± 0.01 7.43 ± 0.06 6.38 ± 0.50 0.6

 Complement C3, g/L 1.14 ± 0.001 1.15 ± 0.001 < 0.001 1.14 ± 0.001 1.14 ± 0.003 1.16 ± 0.021 1.0 1.14 ± 0.001 1.15 ± 0.006 1.08 ± 0.080 0.1

Note: APTT = activated partial thromboplastin time, CRP = C-reactive protein, INR = international normalized ratio, SE = standard error.

*

Unadjusted values from study entry are presented because we were examining differences by genotypes usually unconfounded by cardiovascular risk factors.

Numbers vary slightly depending on availability of measurements.

Wilcoxen rank sum tests and tests for trend.

§

One homozygous participant receiving warfarin was excluded.